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发明授权
US4495185A 1,2,4-Triazin-3(2H) ones 失效
1,2,4-三嗪-3（2H）酮

1,2,4-Triazin-3(2H) ones
摘要：
Heterocyclic compounds of the formula ##STR1## wherein either X is --CR.sup.1 R.sup.2 and Y is --O--, --S-- or --NR.sup.3 --, wherein R.sup.1, R.sup.2 and R.sup.3, which may be the same or different, each is hydrogen or alkyl of up to 4 carbon atoms;or X is --O--, --S-- or --NH-- and Y is --CR.sup.1 R.sup.2 -- wherein R.sup.1 and R.sup.2 have the meanings stated above;wherein either R.sup.4 is hydrogen, fluoro or chloro, or alkyl, alkenyl, halogenoalkyl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or alkoxy each of up to 6 carbon atoms, and R.sup.5, R.sup.6 and R.sup.7, which may be the same or different, each is hydrogen, fluoro, chloro, bromo or iodo, or alkyl, alkenyl, halogenoalkyl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or alkoxy each of up to 6 carbon atoms, provided that R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are not all hydrogen;or R.sup.4 is bromo and R.sup.5, R.sup.6 and R.sup.7 have the meanings stated above, provided that R.sup.5, R.sup.6 and R.sup.7 are not all hydrogen;or R.sup.4 and R.sup.5 together, or R.sup.5 and R.sup.6 together, or R.sup.4 and R.sup.7 together, form the --CH.dbd.CH--CH.dbd.CH-- group and the other two or R.sup.4, R.sup.5, R.sup.6 and R.sup.7 have the meanings stated above; processes for their manufacture and pharmaceutical compositions containing them. The compounds possess cardiotonic and/or antihypertensive activity.
摘要（中）：

其中X是-CR 1 R 2和Y的杂环化合物是其中R 1，R 2和R 3可以相同或不同，各自为氢或烷基， 最多4个碳原子; 或X是-O - ， - S-或-NH-，Y是-CR 1 R 2 - ，其中R 1和R 2具有上述含义; 其中R 4是氢，氟或氯，或至多6个碳原子的烷基，烯基，卤代烷基，氨基烷基，羟基烷基，烷氧基烷基或烷氧基，以及可以相同或不同的R 5，R 6和R 7各自为氢 ，氟，氯，溴或碘，或各自具有至多6个碳原子的烷基，烯基，卤代烷基，氨基烷基，羟基烷基，烷氧基烷基或烷氧基，条件是R4，R5，R6和R7不全部为氢; 或R 4为溴，R 5，R 6和R 7具有上述含义，条件是R 5，R 6和R 7不全为氢; 或R 4和R 5一起，或R 5和R 6一起，或者R 4和R 7一起形成-CH = CH-CH = CH-基，而另外两个或者R 4，R 5，R 6和R 7具有上述含义; 其制造方法和含有它们的药物组合物。 该化合物具有强心剂和/或抗高血压活性。

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