发明授权
US4499310A 5-Methyl-1-(trifluoromethyl)-2-naphthalenol, process for its preparation
and ethers thereof
失效
5-甲基-1-（三氟甲基）-2-萘酚，其制备方法及其醚
- 专利标题： 5-Methyl-1-(trifluoromethyl)-2-naphthalenol, process for its preparation and ethers thereof
- 专利标题（中）： 5-甲基-1-（三氟甲基）-2-萘酚，其制备方法及其醚
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申请号： US506740申请日： 1983-06-22
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公开(公告)号： US4499310A公开(公告)日： 1985-02-12
- 发明人: Kazimir Sestanj , Steven Fung , Nedumparambil A. Abraham , Francesco Bellini
- 申请人： Kazimir Sestanj , Steven Fung , Nedumparambil A. Abraham , Francesco Bellini
- 申请人地址： CAX Montreal
- 专利权人： Ayerst, McKenna & Harrison, Inc.
- 当前专利权人： Ayerst, McKenna & Harrison, Inc.
- 当前专利权人地址： CAX Montreal
- 主分类号： C07C17/16
- IPC分类号： C07C17/16 ; C07C17/26 ; C07C29/58 ; C07C37/06 ; C07C43/225 ; C07C45/00 ; C07C45/42 ; C07C47/575 ; C07C49/223 ; C07C39/14 ; C07C43/20
摘要：
A process and intermediates for preparing 6-(lower alkoxy)-5-(trifluoromethyl)-1-naphthalenecarboxylic acid derivatives are disclosed. The derivatives are useful for preparing aldose reductase inhibitors. With reference to the process, 1,1,1-trifluoro-5-(2-methylphenyl)-2,3-pentadione 3-oxime is cyclized to give a key intermediate 3,4-dihydro-1-hydroxy-5-methyl-1-(trifluoromethyl)-2(1H)-naphthalenone oxime; and 3,4-dihydro-1-hydroxy-5-methyl-1-(trifluoromethyl)-2(1H)-naphthalenone is aromatized to 5-methyl-1-(trifluoromethyl)-2-naphthalenol with a dehydrating agent.
公开/授权文献
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