发明授权
US4505927A 5-Benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and
pharmaceutical use thereof
失效
5-苯甲酰基-1,2-二氢-3H-吡咯并[1,2-a]吡咯-1-羧酸及其药物用途
- 专利标题: 5-Benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and pharmaceutical use thereof
- 专利标题(中): 5-苯甲酰基-1,2-二氢-3H-吡咯并[1,2-a]吡咯-1-羧酸及其药物用途
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申请号: US339813申请日: 1982-01-15
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公开(公告)号: US4505927A公开(公告)日: 1985-03-19
- 发明人: Joseph M. Muchowski , Robert Greenhouse
- 申请人: Joseph M. Muchowski , Robert Greenhouse
- 申请人地址: CA Palo Alto
- 专利权人: Syntex (U.S.A.) Inc.
- 当前专利权人: Syntex (U.S.A.) Inc.
- 当前专利权人地址: CA Palo Alto
- 主分类号: C07D207/34
- IPC分类号: C07D207/34 ; C07D487/04 ; C07D487/06 ; A61K31/40
摘要:
5-benzoyl-7-halo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids, represented by the formula ##STR1## and the pharmaceutically acceptable non-toxic esters and salts thereof, wherein:R is hydrogen or lower alkyl;X is hydrogen, lower alkyl, lower alkoxyl, lower alkoxycarbonyl, carboxyl, lower alkylcarbonyl, sulfonic acid, sulfonic acid alkyl ester, fluoro, chloro, or bromo; and Y is chloro or bromo, which are novel, and 5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids which are represented by the formula ##STR2## wherein X and R are as above defined except that X cannot be chloro or bromo, are prepared by decarboxylation of the corresponding 1,1 dicarboxylates. Intermediates in said preparation are also disclosed.
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