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    5-Aroyl 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1,1-decarboxylates
    2.
    发明授权
    5-Aroyl 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1,1-decarboxylates 失效
    5-芳酰基1,2-二氢-3H-吡咯并[1,2-a]吡咯-1,1-脱羧酸酯

    公开(公告)号：US4458081A

    公开(公告)日：1984-07-03

    申请号：US387564

    申请日：1982-06-11

    申请人： Joseph M. Muchowski ,  Robert Greenhouse

    发明人： Joseph M. Muchowski ,  Robert Greenhouse

    IPC分类号： C07D207/36 ,  C07D487/04 ,  C07D471/04

    CPC分类号： C07D487/04 ,  C07D207/36

    摘要： 5-Substituted-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids of the formula ##STR1## wherein: X is hydrogen or lower alkyl; Ar is a moiety selected from the group consisting of ##STR2## in which: Y is oxygen or sulfur;R is hydrogen, methyl, chloro, or bromo, the R substitution being at the 3, 4 or 5 position of the ring;R.sup.1 is hydrogen, lower alkyl, lower alkoxyl, lower alkoxycarbonyl, lower alkylcarbonyl, fluoro, chloro or bromo, the R.sup.1 substitution being at any available position in the ring;R.sup.2 is hydrogen or lower alkyl;are prepared by .beta.-decarboxylation of the corresponding dialkyl-1,1-dicarboxylates. Certain substituted pyrroles are useful as intermediates for preparing the compounds of formula I.

    摘要翻译： 5-取代的1,2-二氢-3H-吡咯并[1,2-a]吡咯-1-羧酸，其中：X是氢或低级烷基; Ar是选自由以下组成的组的部分：其中：Y为氧或硫; R为氢，甲基，氯或溴，R取代基为环的3,4或5位; R1是氢，低级烷基，低级烷氧基，低级烷氧基羰基，低级烷基羰基，氟，氯或溴，R1取代在环中的任何可用位置; R2是氢或低级烷基; 通过相应的二烷基-1,1-二羧酸的β-脱羧制备。 某些取代的吡咯可用作制备式I化合物的中间体。

    Processes for preparing 5-benzoyl-7-halo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids
    3.
    发明授权
    Processes for preparing 5-benzoyl-7-halo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids 失效
    制备5-苯甲酰基-7-卤代-1,2-二氢-3H-吡咯并〔1,2-a〕吡咯-1-羧酸的方法

    公开(公告)号：US4347185A

    公开(公告)日：1982-08-31

    申请号：US198551

    申请日：1980-10-20

    申请人： Joseph M. Muchowski ,  Robert Greenhouse

    发明人： Joseph M. Muchowski ,  Robert Greenhouse

    IPC分类号： C07D207/34 ,  C07D487/04 ,  A61K31/40 ,  C07D209/00

    CPC分类号： C07D487/04 ,  C07D207/34

    摘要： 5-benzoyl-7-halo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids, represented by the formula ##STR1## and the pharmaceutically acceptable non-toxic esters and salts thereof, wherein:R is hydrogen or lower alkyl;X is hydrogen, lower alkyl, lower alkoxyl, lower alkoxycarbonyl, carboxyl, lower alkylcarbonyl, sulfonic acid, sulfonic acid alkyl ester, fluoro, chloro, or bromo; and Y is chloro or bromo, which are novel, and 5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids which are represented by the formula ##STR2## wherein X and R are as above defined except that X cannot be chloro or bromo, are prepared by decarboxylation of the corresponding 1,1 dicarboxylates. Intermediates in said preparation are also disclosed.

    摘要翻译： 由式（VII）表示的5-苯甲酰基-7-卤代-1,2-二氢-3H-吡咯并[1,2-a]吡咯-1-羧酸和药学上可接受的无毒酯和 其盐，其中：R为氢或低级烷基; X是氢，低级烷基，低级烷氧基，低级烷氧基羰基，羧基，低级烷基羰基，磺酸，磺酸烷基酯，氟，氯或溴; 和Y是氯或溴，它们是新的，由式（VI）表示的5-苯甲酰基-1,2-二氢-3H-吡咯并[1,2-a]吡咯-1-羧酸， 其中X和R如上所定义，除了X不能是氯或溴以外，是通过相应的1,1-二羧酸脱羧制备的。 还公开了所述制备中的中间体。

    5-Aroyl 6-chloro or 6-bromo 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1,1-di-carboxylates
    5.
    发明授权
    5-Aroyl 6-chloro or 6-bromo 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1,1-di-carboxylates 失效
    5-氯代6-氯代或6-溴1,2-二氢-3H-吡咯并[1,2-a]吡咯-1,1-二羧酸盐

    公开(公告)号：US4454326A

    公开(公告)日：1984-06-12

    申请号：US387563

    申请日：1982-06-11

    申请人： Joseph M. Muchowski ,  Robert Greenhouse

    发明人： Joseph M. Muchowski ,  Robert Greenhouse

    IPC分类号： C07D207/36 ,  C07D487/04 ,  C07D471/04

    CPC分类号： C07D487/04 ,  C07D207/36

    摘要： 5-Substituted-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids of the formula ##STR1## wherein: X is hydrogen, lower alkyl, chloro or bromo; Ar is a moiety selected from the group consisting of ##STR2## in which: Y is oxygen or sulfur;R is hydrogen, methyl, chloro, or bromo, the R substitution being at the 3, 4 or 5 position of the ring;R.sup.1 is hydrogen, lower alkyl, lower alkoxyl, lower alkoxycarbonyl, lower alkylcarbonyl, fluoro, chloro or bromo, the R.sup.1 substitution being at any available position in the ring;R.sup.2 is hydrogen or lower alkyl;are prepared by .beta.-decarboxylation of the corresponding dialkyl-1,1-dicarboxylates. Certain substituted pyrroles are useful as intermediates for preparing the compounds of formula I.

    摘要翻译： 5-取代的1,2-二氢-3H-吡咯并[1,2-a]吡咯-1-羧酸，其中：X是氢，低级烷基，氯或溴; Ar是选自下组的部分：其中：Y是氧或硫; R为氢，甲基，氯或溴，R取代基为环的3,4或5位; R1是氢，低级烷基，低级烷氧基，低级烷氧基羰基，低级烷基羰基，氟，氯或溴，R1取代在环中的任何可用位置; R2是氢或低级烷基; 通过相应的二烷基-1,1-二羧酸的β-脱羧制备。 某些取代的吡咯可用作制备式I化合物的中间体。

    Process for preparing 5-aroyl 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein
    6.
    发明授权
    Process for preparing 5-aroyl 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein 失效
    5-芳酰基1,2-二氢-3H-吡咯并[1,2-a]吡咯-1-羧酸及其中间体的制备方法

    公开(公告)号：US4347187A

    公开(公告)日：1982-08-31

    申请号：US272818

    申请日：1981-06-11

    申请人： Joseph M. Muchowski ,  Robert Greenhouse

    发明人： Joseph M. Muchowski ,  Robert Greenhouse

    IPC分类号： C07D207/36 ,  C07D487/04 ,  A61K31/40 ,  C07D209/00

    CPC分类号： C07D487/04 ,  C07D207/36

    摘要： 5-Substituted-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids of the formula ##STR1## wherein: X is hydrogen, lower alkyl, chloro or bromo; Ar is a moiety selected from the group consisting of ##STR2## in which: Y is oxygen or sulfur;R is hydrogen, methyl, chloro, or bromo, the R substitution being at the 3, 4 or 5 position of the ring;R.sup.1 is hydrogen, lower alkyl, lower alkoxyl, lower alkoxycarbonyl, lower alkylcarbonyl, fluoro, chloro or bromo, the R.sup.1 substitution being at any available position in the ring;R.sup.2 is hydrogen or lower alkyl; are prepared by .beta.-decarboxylation of the corresponding dialkyl-1,1-dicarboxylates. Certain substituted pyrroles are useful as intermediates for preparing the compounds of formula I.

    摘要翻译： 5-取代的1,2-二氢-3H-吡咯并[1,2-a]吡咯-1-羧酸，其中：X是氢，低级烷基，氯或溴; Ar是选自下组的部分：其中：Y是氧或硫; R为氢，甲基，氯或溴，R取代基为环的3,4或5位; R1是氢，低级烷基，低级烷氧基，低级烷氧基羰基，低级烷基羰基，氟，氯或溴，R1取代在环中的任何可用位置; R2是氢或低级烷基; 通过相应的二烷基-1,1-二羧酸的β-脱羧制备。 某些取代的吡咯可用作制备式I化合物的中间体。

    Process for preparing 5-aroyl 1,2-dihydro-3-H pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein
    7.
    发明授权
    Process for preparing 5-aroyl 1,2-dihydro-3-H pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein 失效
    5-芳酰基1,2-二氢-3H-吡咯并[1,2-a]吡咯-1-羧酸及其中间体的制备方法

    公开(公告)号：US4347186A

    公开(公告)日：1982-08-31

    申请号：US198552

    申请日：1980-10-20

    申请人： Joseph M. Muchowski ,  Robert Greenhouse

    发明人： Joseph M. Muchowski ,  Robert Greenhouse

    IPC分类号： C07D207/36 ,  C07D487/04 ,  A61K31/40 ,  C07D209/00

    CPC分类号： C07D487/04 ,  C07D207/36

    摘要： 5-Substituted-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids of the formula ##STR1## wherein: X is hydrogen or lower alkyl; Ar is a moiety selected from the group consisting of ##STR2## in which: Y is oxygen or sulfur;R is hydrogen, methyl, chloro, or bromo, the R substitution being at the 3, 4 or 5 position of the ring;R.sup.1 is hydrogen, lower alkyl, lower alkoxyl, lower alkoxycarbonyl, lower alkylcarbonyl, fluoro, chloro or bromo, the R.sup.1 substitution being at any available position in the ring;R.sup.2 is hydrogen or lower alkyl;are prepared by .beta.-decarboxylation of the corresponding dialkyl-1,1-dicarboxylates. Certain substituted pyrroles are useful as intermediates for preparing the compounds of formula I.

    摘要翻译： 5-取代的1,2-二氢-3H-吡咯并[1,2-a]吡咯-1-羧酸，其中：X是氢或低级烷基; Ar是选自由以下组成的组的部分：其中：Y为氧或硫; R为氢，甲基，氯或溴，R取代基为环的3,4或5位; R1是氢，低级烷基，低级烷氧基，低级烷氧基羰基，低级烷基羰基，氟，氯或溴，R1取代在环中的任何可用位置; R2是氢或低级烷基; 通过相应的二烷基-1,1-二羧酸的β-脱羧制备。 某些取代的吡咯可用作制备式I化合物的中间体。