发明授权
- 专利标题： Antibiotic substances DC-45, and their use as medicaments
- 专利标题（中）： 抗生素DC-45及其作为药物的用途
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申请号： US412693申请日： 1982-08-30
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公开(公告)号： US4511560A公开(公告)日： 1985-04-16
- 发明人: Fusao Tomita , Tatsuya Tamaoki , Kunikatsu Shirahata , Takao Iida , Makoto Morimoto , Kazuhisa Fujimoto
- 申请人： Fusao Tomita , Tatsuya Tamaoki , Kunikatsu Shirahata , Takao Iida , Makoto Morimoto , Kazuhisa Fujimoto
- 申请人地址： JPX Tokyo
- 专利权人： Kyowa Hakko Kogyo Kabushiki Kaisha
- 当前专利权人： Kyowa Hakko Kogyo Kabushiki Kaisha
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX54-137734 19791026
- 主分类号： C07H17/04
- IPC分类号： C07H17/04 ; A61K35/74 ; A61P31/04 ; A61P35/00 ; C07G11/00 ; C12P1/06 ; C12R1/465 ; A61K31/71 ; C07H15/26 ; C12P19/56
摘要：
New substances designated as DC-45-A, DC-45-B.sub.1 and DC-45-B.sub.2 and represented by the following general formula: ##STR1## wherein (i) R.sub.1 and R.sub.2 together with the carbon atom therebetween represent the group ##STR2## and R.sub.3 represents ##STR3## (designated DC-45-A); (ii) R.sub.1 represents --OH, R.sub.2 represents --CH.sub.2 OH and R.sub.3 represents ##STR4## (designated DC-45-B.sub.1); or (iii) R.sub.1 and R.sub.2 together with the carbon atom therebetween represent the group ##STR5## and R.sub.3 represents ##STR6## (designated DC-45-B.sub.2). DC-45-A, DC-45-B.sub.1 and DC-45-B.sub.2 possess antibiotic and anti-tumor activity and may be obtained by culturing a microorganism of the genus Streptomyces. Preferred strain is Streptomyces bottropensis (FERM-P No. 5219; NRRL 12051).
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