Sterile, non-metallic bio-compatible hemostatic clips of absorbable and non-absorbable materials comprising two leg members joined with a resilient hinge. The distal ends of said leg members include latch means to lock the clip in a closed position. Each leg member has a vessel clamping inner face and the latch means includes means for preventing relative lateral movement between the vessel clamping inner faces when the clip is in a closed position.