发明授权
US4552898A [3.2.0]Bicycloheptanone oxime ethers with valuable therapeutic properties
失效
[3.2.0]具有宝贵治疗性质的双环庚酮肟醚
- 专利标题: [3.2.0]Bicycloheptanone oxime ethers with valuable therapeutic properties
- 专利标题(中): [3.2.0]具有宝贵治疗性质的双环庚酮肟醚
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申请号: US524711申请日: 1983-08-19
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公开(公告)号: US4552898A公开(公告)日: 1985-11-12
- 发明人: Tsung-Tee Li , Michael Marx
- 申请人: Tsung-Tee Li , Michael Marx
- 申请人地址: CA Palo Alto
- 专利权人: Syntex (U.S.A.) Inc.
- 当前专利权人: Syntex (U.S.A.) Inc.
- 当前专利权人地址: CA Palo Alto
- 主分类号: C07C29/40
- IPC分类号: C07C29/40 ; C07C33/042 ; C07C45/00 ; C07C45/45 ; C07C45/59 ; C07C45/63 ; C07C45/64 ; C07C45/65 ; C07C49/513 ; C07C49/743 ; C07C49/747 ; C07C49/753 ; C07C405/00 ; C07D317/72 ; C07D493/10 ; C07F7/18 ; A61K31/19 ; A61K31/215 ; C07C131/02
摘要:
Compounds useful in treating cardiovascular disorders are the carboxylic acids depicted in formulas (1) and (2) ##STR1## as well as their pharmaceutically acceptable, non-toxic salts and esters, wherein:n is an integer from one to four;R.sub.1 is hydroxy;R.sub.2 is hydrogen; orR.sub.1 and R.sub.2 together are an oxo group;R.sub.3 is ##STR2## wherein A is --CH.sub.2 --CH.sub.2 --; trans--CH.dbd.CH--; --C.tbd.C--; andR.sub.4 is linear or branched alkyl of one to twelve carbons, preferably 1-10 carbons, most preferably 3-8 carbons, cycloalkyl of three to eight carbons; phenyl optionally substituted with one or two identical substituents selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, trifluoromethyl, and halo; or phenylloweralkyl optionally substituted with one or two identical substituents selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, trifluoromethyl, and halo.
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