发明授权
- 专利标题： Matrix composition for transdermal therapeutic system
- 专利标题（中）： 透皮治疗系统的基质组成
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申请号： US491490申请日： 1983-05-04
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公开(公告)号： US4559222A公开(公告)日： 1985-12-17
- 发明人: David J. Enscore , Robert M. Gale
- 申请人： David J. Enscore , Robert M. Gale
- 申请人地址： CA Palo Alto
- 专利权人： ALZA Corporation
- 当前专利权人： ALZA Corporation
- 当前专利权人地址： CA Palo Alto
- 主分类号： A61K35/08
- IPC分类号： A61K35/08 ; A61K9/70 ; A61F13/00 ; A61K31/745 ; A61L15/03
摘要：
Mineral oil (MO) polyisobutylene (PIB), colloidal silicon dioxide (CSD) mixtures suitable for use as drug containing matrices in transdermal delivery systems are disclosed. Preferred systems for dispensing moderately mineral oil soluble drugs contain at least about 6% CSD, have a MO/PIB of at least 1.0 and a viscosity of at least 1.5.times.10.sup.7 poises. Preferred systems for dispensing clonidine have a clonidine permeability of at least 1.0.times.10.sup.-4 .mu.g/cm sec and a MO/PIB of at least 1.2.
公开/授权文献
- US5654381A Functionalized polyester graft copolymers 公开/授权日：1997-08-05
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