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    Synthetic resin matrix system for the extended delivery of drugs
    1.
    发明授权
    Synthetic resin matrix system for the extended delivery of drugs 失效
    合成树脂基体系用于延长药物递送

    公开(公告)号：US4747845A

    公开(公告)日：1988-05-31

    申请号：US815874

    申请日：1986-01-03

    申请人： Bernard Korol

    发明人： Bernard Korol

    IPC分类号： A61K9/22 ,  A61L15/24 ,  A61L15/44 ,  A61L26/00 ,  C08K5/41 ,  A61L15/01 ,  A61L15/03 ,  A61L15/06 ,  C08K5/10 ,  C08K5/15 ,  C08K5/34

    CPC分类号： A61L26/008 ,  A61L15/24 ,  A61L15/44 ,  A61L26/0014 ,  A61L2300/40 ,  A61L2300/414 ,  A61L2300/602 ,  Y10S514/936 ,  Y10S514/946 ,  Y10S514/965

    摘要： A synthetic resin matrix system for the delayed and extended duration delivery of drugs to humans and animals is disclosed consisting of a polymer, such as poly(2-hydroxyethylmethacrylate), referred to as PHEMA, an organic solvent, such as polyethylene glycol (PEG), and a hydrogen binding plasticizer, such as dimethylsulfoxide (DMSO). The plasticizer regulates the set-up time of the synthetic resin so that the more plasticizer present, the shorter the set-up time. The plasticizer also has a direct shortening effect upon the cure time and also profoundly influences many of the physical characteristics of the resultant synthetic resin matrix system. A variety of drugs can be embodied in the fabricated matrix system and administered to the patient (or animal) by different modes of application, including but not limited to oral, topical, rectal, subcutaneous implant, or organ-specific implant such as in the conjunctival sac of the eye. These formulations and procedures can also be utilized in the storage and extended-duration delivery of agricultural products, particularly herbicides, insecticides, and nutritional supplements. By manipulating the relative concentrations of the components of the matrix system and the particle size of the embedded active agent, it is possible to control the release dynamics of the active embodied agent from the matrix and thus provide unique controlled delayed and extended delivery of the active agent.

    摘要翻译： 公开了一种合成树脂基质体系，其用于将药物延迟和延长的持续递送给人和动物，由聚合物如聚（2-羟乙基甲基丙烯酸酯）（称为PHEMA），有机溶剂如聚乙二醇（PEG） ，以及氢结合增塑剂，例如二甲基亚砜（DMSO）。 增塑剂调节合成树脂的安装时间，使得存在的增塑剂越多，安装时间越短。 增塑剂在固化时间上也具有直接的起酥油作用，并且还对所得合成树脂基质体系的许多物理特性产生深刻的影响。 各种药物可以体现在制造的基质体系中，并通过不同的施用方式施用于患者（或动物），包括但不限于口服，局部，直肠，皮下植入或器官特异性植入物，例如在 眼结膜囊 这些制剂和程序也可用于农产品，特别是除草剂，杀虫剂和营养补充剂的储存和延长持续时间的输送。 通过操纵矩阵系统的组分的相对浓度和嵌入的活性剂的粒度，可以从基质中控制活性实施剂的释放动力学，从而提供活性物质的独特的受控延迟和延长递送 代理商

    Drug administration material
    3.
    发明授权
    Drug administration material 失效
    药物管理材料

    公开(公告)号：US4605548A

    公开(公告)日：1986-08-12

    申请号：US632149

    申请日：1984-07-18

    申请人： Keiichi Ushiyama ,  Hisashi Ichinose

    发明人： Keiichi Ushiyama ,  Hisashi Ichinose

    IPC分类号： A61K9/00 ,  A61K9/70 ,  A61L15/03 ,  A61K9/24

    CPC分类号： A61K9/7084 ,  A61K9/006

    摘要： A drug administration material for continuously administering an active drug at a controlled rate through an integument or mucous membrane, which comprises a drug-retaining layer having provided on at least one side thereof a drug administration layer which continuously feeds an active drug to an integument or mucous membrane, said drug administration layer comprising a porous membrane containing in pores thereof a liquid having a limited solubility for the active drug.

    摘要翻译： 一种用于通过皮肤或粘膜以受控速率持续施用活性药物的药物施用材料，其包含药物保持层，所述药物保持层至少在其一侧设置有将活性药物连续供给皮肤的药物施用层，或 所述药物施用层包含在其孔中含有对活性药物的溶解度有限的液体的多孔膜。

    Polymeric diffusion matrix containing estradiol diacetate
    9.
    发明授权
    Polymeric diffusion matrix containing estradiol diacetate 失效
    含有雌二醇二乙酸酯的聚合物扩散基质

    公开(公告)号：US4291014A

    公开(公告)日：1981-09-22

    申请号：US167729

    申请日：1980-07-11

    申请人： Alec D. Keith ,  Wallace Snipes

    发明人： Alec D. Keith ,  Wallace Snipes

    IPC分类号： A61K9/00 ,  A61K9/70 ,  A61K31/565 ,  A61L15/22 ,  A61L15/03 ,  A61K31/79

    CPC分类号： A61K9/7084 ,  A61K31/565 ,  A61K9/0036 ,  A61L15/225

    摘要： There is disclosed a polymeric diffusion matrix for the sustained release of estradiol diacetate by delivery to a patient requiring uterine wall maintenance or other types of estrogen therapy wherein the matrix comprises a polar plasticizer, polyvinylalcohol, polyvinylpyrrolidone, and a pharmaceutically effective amount of estradiol diacetate.

    摘要翻译： 公开了一种用于通过递送到需要子宫壁维持或其它类型的雌激素治疗的患者的持续释放雌二醇二乙酸酯的聚合物扩散基质，其中基质包含极性增塑剂，聚乙烯醇，聚乙烯吡咯烷酮和药学上有效量的雌二醇二乙酸酯。