发明授权
US4598076A 2-pyrrolin-3-carbonitril-derivatives, pharmaceutical compositions
containing them and their anti-inflammatory and ulcer protective
activity
失效
2-吡咯啉-3-腈衍生物,含有它们的药物组合物及其抗炎和溃疡保护活性
- 专利标题: 2-pyrrolin-3-carbonitril-derivatives, pharmaceutical compositions containing them and their anti-inflammatory and ulcer protective activity
- 专利标题(中): 2-吡咯啉-3-腈衍生物,含有它们的药物组合物及其抗炎和溃疡保护活性
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申请号: US691026申请日: 1985-01-14
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公开(公告)号: US4598076A公开(公告)日: 1986-07-01
- 发明人: Hubert Barth , Edgar Fritschi , Volker Ganser , Johannes Hartenstein , Manfred Herrmann , Gerhard Satzinger
- 申请人: Hubert Barth , Edgar Fritschi , Volker Ganser , Johannes Hartenstein , Manfred Herrmann , Gerhard Satzinger
- 申请人地址: NJ Morris Plains
- 专利权人: Warner-Lambert Company
- 当前专利权人: Warner-Lambert Company
- 当前专利权人地址: NJ Morris Plains
- 优先权: DEX3212591 19820403
- 主分类号: C07D207/24
- IPC分类号: C07D207/24 ; A61K31/40 ; A61K31/4015 ; A61K31/4025 ; A61K31/44 ; A61K31/4427 ; A61K31/4433 ; A61K31/445 ; A61K31/495 ; A61K31/535 ; A61P1/04 ; A61P29/00 ; C07D207/36 ; C07D207/38 ; C07D401/04 ; C07D401/14 ; C07D409/04 ; C07D207/277 ; C07D413/12
摘要:
The present invention provides compounds of the general formula I ##STR1## wherein R.sup.1 and R.sup.2, which are the same or different, are unsubstituted or substituted aromatic rings, Alk is a straight-chained or branched lower hydrocarbon chain and Z is a hydrogen atom, with the proviso that when Alk is a straight-chained hydrocarbon chain, Z can also be a lower alkylamino radical of the general formula II ##STR2## in which R.sup.3 and R.sup.4 are the same or different and are hydrogen atoms or straight-chained or branched lower alkyl radicals or R.sup.3 and R.sup.4, together with the nitrogen atom to which they are attached, can also form a ring optionally containing further hetero atoms; and the pharmacologically acceptable salts thereof.The present invention also provides an inventive process for preparing these compounds, as well as pharmaceutical compositions containing them. The compounds I may be used in the therapy of inflammations and they are free of gastrointestinal side effects.
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