发明授权
- 专利标题： Compound, arugomycin
- 专利标题（中）： 化合物，阿鲁木霉素
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申请号： US583180申请日： 1984-02-24
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公开(公告)号： US4598146A公开(公告)日： 1986-07-01
- 发明人: Noboru Otake , Hiroyuki Kawai , Yoichi Hayakawa , Masaya Nakagawa , Kanji Imamura , Kozo Tanabe
- 申请人： Noboru Otake , Hiroyuki Kawai , Yoichi Hayakawa , Masaya Nakagawa , Kanji Imamura , Kozo Tanabe
- 申请人地址： JPX Tokyo
- 专利权人： Kirin Beer Kabushiki Kaisha
- 当前专利权人： Kirin Beer Kabushiki Kaisha
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX58-35663 19830304
- 主分类号： C07G11/00
- IPC分类号： C07G11/00 ; A61K35/74 ; A61P35/00 ; C07H15/252 ; C12P1/06 ; C12P19/56 ; C12R1/465 ; C07H15/24
摘要：
An anthracycline compound, Arugomycin, having the physicochemical properties set forth below is produced by aerobically cultivating an Arugomycin-producing Streptomyces strain in a suitable culture medium, and recovering from the culture the anthracycline compound, Arugomycin.(1) Color and form:Orange powder(2) Melting point:207.degree. to 213.degree. C. (decomposed)(3) Specific rotatory power:[.alpha.].sub.D.sup.25 =+112.degree.(C: 0.1, chloroform:methanol=9:1)(4) Elementary analysis (%):______________________________________ C H O N ______________________________________ Found 56.2 6.9 35.1 1.8 Calcd. 56.7 6.7 34.9 1.7 ______________________________________ (5) Ultraviolet and visible absorption spectrum: as shown in FIG. 1.______________________________________ .lambda..sub.max (E.sup.1% .sub.1cm) ______________________________________ CH.sub.3 OH 235(363), 258(167), 292(61), 476(104) 0.1N HCl + CH.sub.3 OH 235(387), 258(159), 292(61), 468(110) 0.1N NaOH + CH.sub.3 OH 239(302), 294(41), 543(88) ______________________________________ (6) Infrared absorption spectrum (as measured by the potassium bromide method): as shown in FIG. 2.(7) Solubility in solvent:Easily soluble in a chloroform-methanol mixture, dimethyl sulfoxide, pyridine, and basic water.Soluble in chloroform, methanol, ethyl acetate, methyl ethyl ketone, butanol, butyl acetate, ethanol, acetone, and acidic water.Sparingly soluble in water.(8) Thin layer chromatography (using "Silica Gel 60F.sub.254 " plate supplied by Merck & Co., Inc.):______________________________________ Developing solvent Rf value ______________________________________ Chloroform:Methanol (8:1) 0.20 Chloroform:Methanol:29% Aqueous 0.25 ammonia (8:1:0.1) Chloroform:Methanol:Acetic acid 0.30 (8:1:0.1) Chloroform:Benzene:Methanol 0.26 (7:2:2) ______________________________________ (9) NMR spectrum (400 MHz, in deuterochloroform-deuteromethanol): as shown in FIG. 3.(10) Molecular weight (SIMS):m/z 1694 (M+H).
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