发明授权
US4599332A 4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]-ethenyl]-3(2H)-
pyridazinones and related compounds
失效
-4,5-二氢-6- [2- [4-（1H-咪唑-1-基）苯基] - 乙烯基] -3（2H） - 哒嗪酮和相关化合物
- 专利标题： 4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]-ethenyl]-3(2H)- pyridazinones and related compounds
- 专利标题（中）： -4,5-二氢-6- [2- [4-（1H-咪唑-1-基）苯基] - 乙烯基] -3（2H） - 哒嗪酮和相关化合物
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申请号： US669323申请日： 1984-11-09
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公开(公告)号： US4599332A公开(公告)日： 1986-07-08
- 发明人: Ila Sircar
- 申请人： Ila Sircar
- 申请人地址： NJ Morris Plains
- 专利权人： Warner-Lambert Company
- 当前专利权人： Warner-Lambert Company
- 当前专利权人地址： NJ Morris Plains
- 主分类号： C07D403/10
- IPC分类号： C07D403/10 ; C07D521/00 ; A61K31/50
摘要：
4,5-Dihydro-6-[2-[4-(1H -imidazol-1-yl)phenyl]alkylenyl or alkylene-3(2H)-pyridazinones and related compounds and pharmaceutically acceptable acid addition salts thereof are useful as cardiotonic and antihypertensive agents.The above compounds cause a significant increase in myocardial contractility in the dog and also cause a decrease in blood pressure in the spontaneously hypertensive rat. The compounds are produced by reacting the appropriate .gamma.-oxobutanoic acid with a suitably substituted hydrazine to provide 4,5-dihydro-6-[4-[imidazolylphenyl]-alkenylene or alkylene-3(2H)-pyridazinones which may be oxidized to 6-[4-[imidazolylphenyl]alkenylene or alkylene-3(2H)-pyridazinones.
公开/授权文献
- US4016720A Hot-gas reciprocating engine 公开/授权日：1977-04-12
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