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    Novel renin inhibiting peptides
    4.
    发明授权
    Novel renin inhibiting peptides 失效
    新型肾素抑制肽

    公开(公告)号：US5071837A

    公开(公告)日：1991-12-10

    申请号：US621138

    申请日：1990-11-28

    申请人： Annette M. Doherty ,  Ila Sircar

    发明人： Annette M. Doherty ,  Ila Sircar

    IPC分类号： A61K38/00 ,  C07K5/02

    CPC分类号： C07K5/0205 ,  A61K38/00

    摘要： The invention concerns certain orally active novel renin-inhibitory peptides which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism, and glaucoma. It is also useful for treating diseases caused by retroviruses including HTLV-I, -II, and -III. Process for preparing the peptides, compositions containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension, congestive heart failure, or hyperaldosteronism.

    摘要翻译： 本发明涉及可用于治疗肾素相关性高血压，充血性心力衰竭，醛固酮增多症和青光眼的某些口服活性的新型肾素抑制肽。 它也可用于治疗由逆转录病毒引起的疾病，包括HTLV-1，-II和-III。 包括肽的制备方法，含有它们的组合物和使用它们的方法。 还包括使用该化合物来确定肾素相关性高血压，充血性心力衰竭或醛固酮增多症的存在的诊断方法。

    Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents
    7.
    发明授权
    Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents 失效
    用作强心剂的取代的6-苯基-3（2H） - 哒嗪酮

    公开(公告)号：US4404203A

    公开(公告)日：1983-09-13

    申请号：US263643

    申请日：1981-05-14

    申请人： Ila Sircar

    发明人： Ila Sircar

    IPC分类号： A61K31/50 ,  C07D237/14 ,  C07D237/04 ,  C07D237/24

    CPC分类号： A61K31/50

    摘要： Substituted 6-phenyl-3(2H)-pyridazinone compounds are useful as cardiotonic agents.Said compounds cause a significant increase in myocardial contractility in the anesthetized dog. Said compounds are produced by reacting substituted benzoylpropionic acids with suitably substituted hydrazines to provide 6-phenyl-4,5-dihydro-3(2H)-pyridazinones which are dehydrogenated to the desired product.The intermediate 6-phenyl-4,5-dihydro-3(2H)-pyridazinones are themselves useful as cardiotonic agents.

    摘要翻译： 取代的6-苯基-3（2H） - 哒嗪酮化合物可用作强心剂。 所述化合物引起麻醉狗中心肌收缩力的显着增加。 所述化合物通过使取代的苯甲酰基丙酸与适当取代的肼反应制得，得到6-苯基-4,5-二氢-3（2H） - 哒嗪酮，将其脱氢成所需产物。 中间体6-苯基-4,5-二氢-3（2H） - 哒嗪酮本身可用作强心剂。