发明授权
- 专利标题: Benzazepine derivatives
- 专利标题(中): 苯扎西平衍生物
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申请号: US732204申请日: 1985-05-08
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公开(公告)号: US4604389A公开(公告)日: 1986-08-05
- 发明人: Manfred Reiffen , Klaus Noll , Joachim Heider , Volkhard Austel , Norbert Hauel , Walter Kobinger , Christian Lillie
- 申请人: Manfred Reiffen , Klaus Noll , Joachim Heider , Volkhard Austel , Norbert Hauel , Walter Kobinger , Christian Lillie
- 申请人地址: DEX Biberach an der Riss
- 专利权人: Dr. Karl Thomae GmbH
- 当前专利权人: Dr. Karl Thomae GmbH
- 当前专利权人地址: DEX Biberach an der Riss
- 优先权: DEX3418271 19840517
- 主分类号: A61K31/55
- IPC分类号: A61K31/55 ; A61P9/06 ; C07C59/64 ; C07D223/16 ; C07D233/16 ; C07D243/04 ; C07D405/12 ; C07D491/04 ; C07D491/056 ; C07D521/00
摘要:
This invention relates to benzazepine derivatives of formula I ##STR1## wherein A is --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--;R.sub.1 is hydrogen, chlorine, bromine, C.sub.1 -C.sub.3 alkyl, amino, C.sub.1 -C.sub.3 alkylamino, C.sub.1 -C.sub.3 dialkylamino, acylamino, hydroxy, C.sub.1 -C.sub.3 alkoxy or phenyl C.sub.1 -C.sub.3 alkoxy;R.sub.2 is hydrogen, chlorine, bromine, hydroxy, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy or phenyl C.sub.1 -C.sub.3 alkoxy or, together with R.sub.1, can be C.sub.1 -C.sub.3 alkylenedioxy;R.sub.3 is hydrogen, chlorine, bromine or C.sub.1 -C.sub.3 alkoxy;R.sub.4 is hydrogen, benzyl, C.sub.1 -C.sub.3 alkyl or C.sub.3 -C.sub.5 alkenyl;R.sub.5 is hydrogen, halogen, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy;R.sub.6 is hydrogen, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy or, together with R.sub.5, can be a C.sub.1 -C.sub.2 alkylenedioxy;X is an imino, optionally substituted by a benzyl or C.sub.1 -C.sub.3 alkyl, or is oxygen, sulphur, sulphinyl or sulphonyl;Y is an imino, optionally substituted by a benzyl or C.sub.1 -C.sub.3 alkyl, or is methylene or carbonyl;m and n are each independently 2, 3 or 4; and nontoxic, pharmaceutically acceptable addition salts thereof. These compounds have valuable pharmacological properties, particularly the effect of lowering heart rate and reducing the O.sub.2 requirement of the heart.
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