公开(公告)号：US11524938B2

公开(公告)日：2022-12-13

申请号：US17067434

申请日：2020-10-09

申请人： Bayer Pharma Aktiengesellschaft

发明人： Stefan Werner ,  Stefanie Mesch ,  Arwed Cleve ,  Nico Bräuer ,  Simon Anthony Herbert ,  Markus Koch ,  Henrik Dahllöf ,  Maren Osmers ,  Elizabeth Hardaker ,  Anton Lishchynskyi

IPC分类号： C07D213/64 ,  C07D403/06 ,  C07D231/14 ,  C07D231/16 ,  C07D231/18 ,  C07D233/61 ,  C07D233/64 ,  C07D233/68 ,  C07D401/04 ,  C07D403/04 ,  C07D405/06 ,  C07D239/34 ,  C07D249/06 ,  C07D249/08 ,  C07D249/14 ,  C07D471/04 ,  C07D261/08 ,  C07D271/06 ,  C07C311/46 ,  C07F5/02 ,  C07D207/416 ,  C07D231/56 ,  C07D213/85 ,  C07D277/56 ,  C07D249/20 ,  C07D213/60 ,  C07C311/17 ,  C07D213/61 ,  C07D239/30 ,  C07D239/42 ,  C07D249/10 ,  C07D213/65 ,  C07D249/12 ,  C07D233/16 ,  C07C323/62 ,  C07D237/08 ,  C07D213/40 ,  C07D239/26 ,  C07D235/06 ,  C07C311/40 ,  C07D213/74 ,  C07D405/04 ,  C07D271/04 ,  C07D277/26 ,  C07D249/18 ,  C07D277/34 ,  C07D275/02 ,  C07D263/32 ,  C07D231/38 ,  C07D207/333 ,  A61P29/00 ,  C07D235/08 ,  C07D401/12 ,  C07D231/12

摘要： Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease.

公开(公告)号：US20220161246A1

公开(公告)日：2022-05-26

申请号：US17420409

申请日：2019-08-19

申请人： PAIMAI NEW MATERIALS (CHENGDU) CO., LTD.

发明人： Jianxin CHEN

IPC分类号： B01J31/22 ,  C08G61/08 ,  C07D233/16 ,  C07C67/333 ,  C07F15/00 ,  C07D487/04

摘要： Nitrogen heterocyclic carbine ligands and ruthenium catalysts thereof, a preparation method therefor and an application thereof are provided. The structures of the nitrogen heterocyclic carbine ligands are represented by formulas Ia and Ib, respectively, and the corresponding ruthenium catalyst structures are represented by IIa and IIb, respectively. After simultaneously introducing large-steric hindrance and electron-rich groups into the described nitrogen heterocyclic carbine ligand structures, the catalytic activity, stability and application range of the ruthenium complex catalysts thereof are significantly improved.

公开(公告)号：US10702498B2

公开(公告)日：2020-07-07

申请号：US15743079

申请日：2016-06-30

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  FRIEDRICH-ALEXANDER-UNIVERSITÃT ERLANGEN-NÜRNBERG ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY ,  THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

发明人： Brian K. Shoichet ,  Henry Lin ,  Peter Gmeiner ,  Aashish Manglik ,  Brian Kobilka ,  Bryan L. Roth ,  Daniela Gisela Dengler

IPC分类号： C07C275/26 ,  A61K31/381 ,  C07D401/12 ,  C07C275/24 ,  C07D207/452 ,  C07D233/16 ,  C07D498/18 ,  C07D333/16 ,  C07D249/04 ,  C07D409/12 ,  C07D471/04 ,  C07D333/20 ,  C07D295/125 ,  C07D333/58 ,  C07D495/04 ,  A61P25/36 ,  A61K31/165 ,  A61K31/17

摘要： Described herein, inter alia, are compositions and methods for modulating mu opioid receptor activity.

公开(公告)号：US10669673B2

公开(公告)日：2020-06-02

申请号：US15868073

申请日：2018-01-11

申请人： GPCP IP Holdings LLC

发明人： Yu Chen ,  Kevin M. Holtman ,  Brian S. Hammes ,  Jeffrey J. Boettcher

IPC分类号： D21H21/24 ,  D21H21/20 ,  D21H17/07 ,  C07D233/16 ,  D21H17/20 ,  D21H27/00 ,  D21H17/14 ,  D21H17/37 ,  D21H21/18 ,  D21H21/22 ,  D21H17/06 ,  D21H17/00 ,  D21H23/06

摘要： Absorbent sheet is manufactured utilizing a low charge density debonder composition comprising an imidazolinium surfactant-containing constituent selected from the group consisting of: (i) cationic imidazolinium surfactants with alkylalkenylhydroxy substitution; (ii) zwitterionic imidazolinium surfactants; and (iii) an ion paired surfactant mixture including a zwitterionic imidazolinium surfactant and a cationic surfactant and, in admixture with the imidazolinium surfactant-containing constituent, (iv) a nonionic surfactant.

公开(公告)号：US20190330515A1

公开(公告)日：2019-10-31

申请号：US16448895

申请日：2019-06-21

申请人： Ingevity South Carolina, LLC

发明人： Kimberley D. Macewan ,  Reinaldo C. Navarrete ,  Chao Yang

IPC分类号： C09K8/584 ,  E21B47/00 ,  E21B43/16 ,  C07D233/06 ,  C07D233/16 ,  C07D209/56 ,  C07D209/48 ,  C07D207/40 ,  C07C305/06

摘要： A method of enhanced oil recovery wherein: (a) a flooding composition is delivered into a subterranean reservoir; (b) the flooding composition includes a sulfur surfactant; and (c) the fluid produced from the subterranean reservoir can also be analyzed to determine if the surfactant is present in the fluid. The surfactant preferably includes a sulfonate moiety or other sulfur-containing moiety. The presence of the surfactant in the fluid produced from the subterranean reservoir is preferably determined by X-ray fluorescence spectroscopy, HPLC-AES, or HPLC-ICP.

公开(公告)号：US07812047B2

公开(公告)日：2010-10-12

申请号：US12146497

申请日：2008-06-26

申请人： Guido Galley ,  Katrin Groebke Zbinden ,  Roger Norcross ,  Henri Stalder

发明人： Guido Galley ,  Katrin Groebke Zbinden ,  Roger Norcross ,  Henri Stalder

IPC分类号： A61K31/4174 ,  C07D233/12 ,  C07D233/16

CPC分类号： C07D233/06 ,  C07D233/12 ,  C07D233/22 ,  C07D233/24

摘要： The present invention relates to compounds of formula wherein R1, R2, X, Y and Ar are as defined herein and to their pharmaceutically active salts, with the exclusion of the racemic compound 4-benzyl-4,5-dihydro-1H-imidazole or its tautomer (CAS 131548-83-9). Compounds of formula I have a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1 and are useful for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.

摘要翻译： 本发明涉及下式的化合物，其中R 1，R 2，X，Y和Ar如本文所定义及其药学活性盐，排除外消旋化合物4-苄基-4,5-二氢-1H-咪唑或 其互变异构体（CAS 131548-83-9）。 式I化合物对微量胺相关受体（TAAR）具有良好的亲和力，尤其对于TAAR1，可用于治疗抑郁症，焦虑障碍，双相情感障碍，注意缺陷多动障碍（ADHD），应激相关疾病，精神病性 诸如精神分裂症，神经系统疾病如帕金森病，神经变性疾病如阿尔茨海默氏病，癫痫，偏头痛，高血压，药物滥用和代谢性疾病如进食障碍，糖尿病，糖尿病并发症，肥胖症，血脂异常，能量消耗和同化障碍等疾病 ，体温平衡紊乱和失眠，睡眠障碍和昼夜节律，以及心血管疾病。

公开(公告)号：US20060194965A1

公开(公告)日：2006-08-31

申请号：US11359263

申请日：2006-02-22

申请人： Stephane Horvath ,  Marie-Noelle Auguste ,  Gerard Damien

发明人： Stephane Horvath ,  Marie-Noelle Auguste ,  Gerard Damien

IPC分类号： C07D233/16

CPC分类号： C07D223/16 ,  B01J21/04 ,  B01J23/50 ,  B01J23/62 ,  B01J23/622 ,  B01J23/626 ,  B01J23/892 ,  B01J23/8926 ,  B01J35/0013 ,  B01J35/006 ,  B01J35/008 ,  B01J37/0211 ,  B01J37/0213 ,  C10G45/34

摘要： A βd-Crystalline form of ivabradine hydrochloride of formula (I): characterised by its powder X-ray diffraction data. Medicinal products containing the same which are useful as bradycardics.

公开(公告)号：US07005087B2

公开(公告)日：2006-02-28

申请号：US10748725

申请日：2003-12-30

申请人： David Youdong Tong

发明人： David Youdong Tong

IPC分类号： C09K15/16 ,  C07D233/16 ,  C07D27/40 ,  C07C57/18

CPC分类号： C08K5/3415 ,  C07C51/50 ,  C08K5/3445 ,  C07C57/04

摘要： A composition comprising aminoalkyl imidazoline or alkyl-substituted succinimide antifoulants or mixtures thereof, and use of aminoalkyl imidazolines and alkyl-substituted succinimides to prevent fouling in (meth)acrylic acid manufacturing processes and processes in which (meth)acrylic acid is used in a reaction and where unreacted (meth)acrylic acid is recovered.

摘要翻译： 包含氨基烷基咪唑啉或烷基取代的琥珀酰亚胺防污剂或其混合物的组合物，以及使用氨基烷基咪唑啉和烷基取代的琥珀酰亚胺以防止（甲基）丙烯酸制造方法中的结垢和其中在反应中使用（甲基）丙烯酸的方法 并回收未反应的（甲基）丙烯酸。

公开(公告)号：US06911546B2

公开(公告)日：2005-06-28

申请号：US10330853

申请日：2002-12-26

申请人： James Lupton Hedrick ,  Pinar Kilickiran ,  Gregory Walker Nyce ,  Robert M. Waymouth

发明人： James Lupton Hedrick ,  Pinar Kilickiran ,  Gregory Walker Nyce ,  Robert M. Waymouth

IPC分类号： C07C59/285 ,  C07C67/03 ,  C07C68/06 ,  C07D233/02 ,  C07D233/04 ,  C07D233/06 ,  C07D233/16 ,  C07D233/54 ,  C07D307/33 ,  C07F1/00 ,  C07D233/38 ,  C07F2/46

CPC分类号： C07D233/16 ,  C07C59/285 ,  C07C67/03 ,  C07C68/06 ,  C07D233/02 ,  C07D233/04 ,  C07D233/06 ,  C07D233/54 ,  C07D307/33 ,  C07F1/00 ,  C07C69/82 ,  C07C69/96

摘要： A method is provided for carrying out depolymerization of a polymer containing electrophilic linkages in the presence of a catalyst and a nucleophilic reagent, wherein production of undesirable byproducts resulting from polymer degradation is minimized. The reaction can be carried out at a temperature of 80° C. or less, and generally involves the use of an organic, nonmetallic catalyst, thereby ensuring that the depolymerization product(s) are substantially free of metal contaminants. In an exemplary depolymerization method, the catalyst is a carbene compound such as an N-heterocyclic carbene, or is a precursor to a carbene compound. The method provides an important alternative to current recycling techniques such as those used in the degradation of polyesters, polyamides, and the like.

摘要翻译： 提供了一种在催化剂和亲核试剂的存在下进行含有亲电键的聚合物解聚的方法，其中由聚合物降解产生的不需要的副产物的产生最小化。 反应可以在80℃或更低的温度下进行，通常涉及使用有机非金属催化剂，从而确保解聚产物基本上不含金属污染物。 在示例性的解聚方法中，催化剂是卡宾化合物如N-杂环卡宾，或是卡宾化合物的前体。 该方法提供了当前回收技术的重要替代方法，例如用于降解聚酯，聚酰胺等的那些。

公开(公告)号：US06903220B2

公开(公告)日：2005-06-07

申请号：US10439313

申请日：2003-05-15

申请人： Mukund S. Chorghade ,  Mukund K. Gurjar ,  Bhanu M. Chanda

发明人： Mukund S. Chorghade ,  Mukund K. Gurjar ,  Bhanu M. Chanda

IPC分类号： C07D233/64 ,  A61K31/426 ,  A61P7/02 ,  A61P11/06 ,  A61P29/00 ,  A61P31/12 ,  C07B53/00 ,  C07B55/00 ,  C07B61/00 ,  C07C217/46 ,  C07C227/18 ,  C07C229/06 ,  C07C229/42 ,  C07C249/02 ,  C07C253/00 ,  C07C255/53 ,  C07C255/54 ,  C07C257/08 ,  C07C319/02 ,  C07C319/06 ,  C07C319/12 ,  C07C319/20 ,  C07C323/00 ,  C07C323/25 ,  C07C323/35 ,  C07C323/52 ,  C07C323/56 ,  C07C323/58 ,  C07D213/55 ,  C07D233/16 ,  C07D237/02 ,  C07D277/04 ,  C07D277/08 ,  C07D277/12 ,  C07D277/14 ,  C07D277/18 ,  C07D277/56 ,  C07D303/24 ,  C07C321/00

CPC分类号： C07C227/18 ,  C07B2200/07 ,  C07C229/36 ,  C07C255/53 ,  C07C255/54 ,  C07C257/08 ,  C07C319/02 ,  C07C319/06 ,  C07C319/12 ,  C07C319/20 ,  C07D277/12 ,  C07D303/24 ,  C07C323/58

摘要： Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. A method of preparing a 2-alkyl amino acid involves reacting cysteine (or a salt or an ester thereof) and an aryl carboxylic acid to form a thiazoline ring, stereospecifically alkylating the thiazoline ring, and hydrolyzing the thiazoline ring to obtain a 2-alkylcysteine (or related compound). The present invention also discloses a method of preparing a class of iron chelating agents related to desferrithiocin, all of which contain a thiazoline ring. In this method, an aryl nitrile or imidate is condensed with cysteine, a 2-alkyl cysteine, or a cysteine ester.

摘要翻译： 非天然氨基酸例如2-烷基化氨基酸允许合成更多种类的肽和非肽类药物活性剂。 制备2-烷基氨基酸的方法包括使半胱氨酸（或其盐或其酯）和芳基羧酸反应形成噻唑啉环，立体特异性烷基化噻唑啉环，并水解噻唑啉环以获得2-烷基半胱氨酸 （或相关化合物）。 本发明还公开了一种制备与脱铁硫杆菌相关的一类铁螯合剂的方法，所述铁螯合剂全部含有噻唑啉环。 在该方法中，芳基腈或亚氨酸酯与半胱氨酸，2-烷基半胱氨酸或半胱氨酸酯缩合。