发明授权
US4604397A Certain benzo-(pyrano and thiopyrano)-pyridines, useful as CNS agents
失效
某些苯并(吡喃和噻喃)吡啶,可用作CNS剂
- 专利标题: Certain benzo-(pyrano and thiopyrano)-pyridines, useful as CNS agents
- 专利标题(中): 某些苯并(吡喃和噻喃)吡啶,可用作CNS剂
-
申请号: US771934申请日: 1985-09-03
-
公开(公告)号: US4604397A公开(公告)日: 1986-08-05
- 发明人: Alan J. Hutchison
- 申请人: Alan J. Hutchison
- 申请人地址: NY Ardsley
- 专利权人: Ciba-Geigy Corporation
- 当前专利权人: Ciba-Geigy Corporation
- 当前专利权人地址: NY Ardsley
- 优先权: EPX85810208.0 19850506
- 主分类号: A61K31/435
- IPC分类号: A61K31/435 ; A61P25/00 ; A61P25/02 ; A61P25/18 ; A61P25/20 ; A61P25/24 ; A61P25/26 ; A61P25/28 ; C07D209/48 ; C07D311/22 ; C07D311/58 ; C07D335/06 ; C07D405/06 ; C07D491/04 ; C07D491/052 ; C07D491/113 ; C07D495/04 ; A61K31/38 ; A61K31/395 ; C07D471/02 ; C07D491/02
摘要:
Disclosed are the compounds of formula I ##STR1## wherein X represents oxygen or sulfur; ring A is unsubstituted or substituted by one to three identical or different substituents selected from hydroxy, hydroxy-lower alkyl, etherified hydroxy, etherified hydroxy-lower alkyl, acyloxy, acyloxy-lower alkyl, halogen, lower alkyl, trifluoromethyl, amino, mono- and di-lower alkylamino and acylamino; or ring A is substituted by one lower alkylenedioxy; R represents hydrogen, lower alkyl or aryl-lower alkyl; R.sub.1 represents hydrogen, lower alkyl, lower alkylthio-lower alkyl, amino, acylamino, (amino, mono- or di-lower alkylamino)-lower alkyl, carboxy, lower alkoxycarbonyl, carbamoyl or mono- or di-lower alkylcarbamoyl; R.sub.2 to R.sub.5 represent hydrogen or lower alkyl; the dehydro derivatives thereof with a double bond at the 1,2-position, or at the 1,10b-position in which case R.sub.5 is absent; or a pharmaceutically acceptable salt thereof; methods for their synthesis; pharmaceutical compositions thereof; and use thereof as psychactive agents for the treatment of central nervous system disorders.
公开/授权文献
- US5705548A Polyester powder coating composition 公开/授权日:1998-01-06
信息查询