发明授权
- 专利标题: 1-oxadethiacepham compounds
- 专利标题(中): 1-恶嗪硫醚化合物
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申请号: US542520申请日: 1983-10-17
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公开(公告)号: US4604460A公开(公告)日: 1986-08-05
- 发明人: Mitsuru Yoshioka , Uyeo Shoichiro , Yoshio Hamashima , Ikuo Kikkawa , Teruji Tsuji , Wataru Nagata
- 申请人: Mitsuru Yoshioka , Uyeo Shoichiro , Yoshio Hamashima , Ikuo Kikkawa , Teruji Tsuji , Wataru Nagata
- 申请人地址: JPX Osaka
- 专利权人: Shionogi & Co., Ltd.
- 当前专利权人: Shionogi & Co., Ltd.
- 当前专利权人地址: JPX Osaka
- 优先权: JPX52-15813 19770215; JPX52-67025 19770606; JPX55-138092 19801001
- 主分类号: C07D498/04
- IPC分类号: C07D498/04 ; C07D498/20 ; C07D505/00
摘要:
Intermediates for preparaing an antibacterial 1-dethia-1-oxacephalosporins which are represented by the following formula: ##STR1## wherein R is a monovalent group (minus the carbonyl) from an acyl derived from a carboxylic or carbonic acid;Y.sup.1 is a divalent group of the following formula: ##STR2## wherein COB is carboxy or protected carboxy;X is hydrogen or a nucleophilic group; andZ is a leaving groupare prepared from a compound of the following formula: ##STR3## wherein R and Y.sup.1 are as defined aboveby the action of an acid.The new compounds of this invention shown by the following formula: ##STR4## wherein A is amino or substituted amino;E is hydrogen or methoxy; andY is a divalent group of the following formula: ##STR5## in which COB, X, and Z are as defined above are convertible into other compounds of the same formula by applying conventional methods in .beta.-lactam chemistry.
公开/授权文献
- US5581150A TFEL device with injection layer 公开/授权日:1996-12-03