公开(公告)号：US4604460A

公开(公告)日：1986-08-05

申请号：US542520

申请日：1983-10-17

申请人： Mitsuru Yoshioka ,  Uyeo Shoichiro ,  Yoshio Hamashima ,  Ikuo Kikkawa ,  Teruji Tsuji ,  Wataru Nagata

发明人： Mitsuru Yoshioka ,  Uyeo Shoichiro ,  Yoshio Hamashima ,  Ikuo Kikkawa ,  Teruji Tsuji ,  Wataru Nagata

IPC分类号： C07D498/04 ,  C07D498/20 ,  C07D505/00

CPC分类号： C07D505/00

摘要： Intermediates for preparaing an antibacterial 1-dethia-1-oxacephalosporins which are represented by the following formula: ##STR1## wherein R is a monovalent group (minus the carbonyl) from an acyl derived from a carboxylic or carbonic acid;Y.sup.1 is a divalent group of the following formula: ##STR2## wherein COB is carboxy or protected carboxy;X is hydrogen or a nucleophilic group; andZ is a leaving groupare prepared from a compound of the following formula: ##STR3## wherein R and Y.sup.1 are as defined aboveby the action of an acid.The new compounds of this invention shown by the following formula: ##STR4## wherein A is amino or substituted amino;E is hydrogen or methoxy; andY is a divalent group of the following formula: ##STR5## in which COB, X, and Z are as defined above are convertible into other compounds of the same formula by applying conventional methods in .beta.-lactam chemistry.

摘要翻译： 用于制备由下式表示的抗细菌1-脱氧-1-氧环孢菌素的中间体：其中R是衍生自羧酸或碳酸的酰基的一价基团（减去羰基）; Y1是下式的二价基团：其中COB是羧基或被保护的羧基; X是氢或亲核基团; 并且Z是离去基团由下式的化合物制备：其中R和Y1如上所定义，通过酸的作用。 本发明的新化合物由下式表示：其中A是氨基或取代的氨基; E是氢或甲氧基; 并且Y是下式的二价基团：其中COB，X和Z如上定义的 + TR 可通过在β-内酰胺化学中应用常规方法转化为相同式的其它化合物。

公开(公告)号：US4443598A

公开(公告)日：1984-04-17

申请号：US374862

申请日：1982-05-04

申请人： Mitsuru Yoshioka ,  Uyeo Shoichiro ,  Yoshio Hamashima ,  Ikuo Kikkawa ,  Teruji Tsuji ,  Wataru Nagata

发明人： Mitsuru Yoshioka ,  Uyeo Shoichiro ,  Yoshio Hamashima ,  Ikuo Kikkawa ,  Teruji Tsuji ,  Wataru Nagata

IPC分类号： C07D498/04 ,  C07D505/00

CPC分类号： C07D505/00

摘要： Intermediates for preparing an antibacterial 1-dethia-1-oxacephalosporins which are represented by the following formula: ##STR1## wherein R is a monovalent group (minus the carbonyl) from an acyl derived from a carboxylic or carbonic acid;Y.sup.1 is a divalent group of the following formula: ##STR2## wherein COB is carboxy or protected carboxy;X is hydrogen or a nucleophilic group; andZ is a leaving groupare prepared from a compound of the following formula: ##STR3## wherein R and Y.sup.1 are as defined above by the action of an acid. The new compounds of this invention shown by the following formula: ##STR4## wherein A is amino or substituted amino;E is hydrogen or methoxy; andY is a divalent group of the following formula: ##STR5## in which COB, X, and Z are as defined above are convertible into other compounds of the same formula by applying conventional methods in .beta.-lactam chemistry.

摘要翻译： 用于制备由下式表示的抗菌1-脱氧-1-氧杂头孢菌素的中间体：其中R是衍生自羧酸或碳酸的酰基的一价基团（减去羰基）; Y1是下式的二价基团：其中COB是羧基或被保护的羧基; X是氢或亲核基团; 并且Z是离去基团由下式的化合物制备：其中R和Y1如上所定义，通过酸的作用。 本发明的新化合物由下式表示：其中A是氨基或取代的氨基; E是氢或甲氧基; 并且Y是下式的二价基团：其中COB，X和Z如上定义的 + TR 可通过在β-内酰胺化学中应用常规方法转化为相同式的其它化合物。

公开(公告)号：US4533730A

公开(公告)日：1985-08-06

申请号：US543940

申请日：1983-10-19

申请人： Mitsuru Yoshioka ,  Uyeo Shoichiro ,  Yoshio Hamashima ,  Ikuo Kikkawa ,  Teruji Tsuji ,  Wataru Nagata

发明人： Mitsuru Yoshioka ,  Uyeo Shoichiro ,  Yoshio Hamashima ,  Ikuo Kikkawa ,  Teruji Tsuji ,  Wataru Nagata

IPC分类号： C07D498/04 ,  C07D498/20 ,  C07D505/00

CPC分类号： C07D505/00

摘要： Intermediates for preparing an antibacterial 1-dethia-1-oxacephalosporins which are represented by the following formula: ##STR1## wherein R is a monovalent group (minus the carbonyl) from an acyl derived from a carboxylic or carbonic acid;Y.sup.1 is a divalent group of the following formula: ##STR2## wherein COB is carboxy or protected carboxy;X is hydrogen or a nucleophilic group; andZ is a leaving groupare prepared from a compound of the following formula; ##STR3## wherein R and Y.sup.1 are as defined above by the action of an acid. The new compounds of this invention shown by the following formula: ##STR4## wherein A is amino or substituted amino;E is hydrogen or methoxy; andY is a divalent group of the following formula: ##STR5## in which COB, X, and Z are as defined above are convertible into other compounds of the same formula by applying conventional methods in .beta.-lactam chemistry.

摘要翻译： 用于制备由下式表示的抗菌1-脱氧-1-氧杂头孢菌素的中间体：其中R是衍生自羧酸或碳酸的酰基的一价基团（减去羰基）; Y1是下式的二价基团：其中COB是羧基或被保护的羧基; X是氢或亲核基团; 并且Z为离去基团由下式的化合物制备： 其中R和Y1如上所定义，通过酸的作用。 本发明的新化合物由下式表示：其中A是氨基或取代的氨基; E是氢或甲氧基; 并且Y是下式的二价基团：其中COB，X和Z如上定义的 + TR 可通过在β-内酰胺化学中应用常规方法转化为相同式的其它化合物。

公开(公告)号：US4504659A

公开(公告)日：1985-03-12

申请号：US543939

申请日：1983-10-19

申请人： Mitsuru Yoshioka ,  Uyeo Shoichiro ,  Yoshio Hamashima ,  Ikuo Kikkawa ,  Teruji Tsuji ,  Wataru Nagata

发明人： Mitsuru Yoshioka ,  Uyeo Shoichiro ,  Yoshio Hamashima ,  Ikuo Kikkawa ,  Teruji Tsuji ,  Wataru Nagata

IPC分类号： C07D498/04 ,  C07D498/20 ,  C07D505/00

CPC分类号： C07D505/00

摘要： Intermediates for preparing an antibacterial 1-dethia-1-oxacephalosporins which are represented by the following formula: ##STR1## wherein R is a monovalent group (minus the carbonyl) from an acyl derived from a carboxylic or carbonic acid;Y.sup.1 is a divalent group of the following formula: ##STR2## wherein COB is carboxy or protected carboxy;X is hydrogen or a nucleophilic group; andZ is a leaving groupare prepared from a compound of the following formula: ##STR3## wherein R and Y.sup.1 are as defined above by the action of an acid.

摘要翻译： 用于制备由下式表示的抗菌1-脱氧-1-氧杂头孢菌素的中间体：其中R是衍生自羧酸或碳酸的酰基的一价基团（减去羰基）; Y1是下式的二价基团：其中COB是羧基或被保护的羧基; X是氢或亲核基团; 并且Z是离去基团由下式的化合物制备：其中R和Y1如上所定义，通过酸的作用。