发明授权
US4609672A 1-(Alkanoylamino-aryloxy)-2-hydroxy-3-(alkinyl-amino)-propanes and salts
thereof
失效
1-(烷酰基氨基 - 芳氧基)-2-羟基-3-(炔基 - 氨基) - 丙烷及其盐
- 专利标题: 1-(Alkanoylamino-aryloxy)-2-hydroxy-3-(alkinyl-amino)-propanes and salts thereof
- 专利标题(中): 1-(烷酰基氨基 - 芳氧基)-2-羟基-3-(炔基 - 氨基) - 丙烷及其盐
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申请号: US623960申请日: 1984-06-25
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公开(公告)号: US4609672A公开(公告)日: 1986-09-02
- 发明人: Herbert Koppe , Werner Kummer , Helmut Stahle , Gojko Muacevic , Werner Traunecker
- 申请人: Herbert Koppe , Werner Kummer , Helmut Stahle , Gojko Muacevic , Werner Traunecker
- 申请人地址: DEX Ingelheim am Rhein
- 专利权人: C. H. Boehringer Sohn
- 当前专利权人: C. H. Boehringer Sohn
- 当前专利权人地址: DEX Ingelheim am Rhein
- 优先权: DEX3009047 19800308
- 主分类号: A61K31/275
- IPC分类号: A61K31/275 ; A61K31/505 ; A61P9/00 ; C07C67/00 ; C07C253/00 ; C07C255/59 ; C07C255/60
摘要:
The invention relates to a compound of the formula ##STR1## wherein R.sub.1 is a linear or branched alkyl of 4 to 20 carbon atoms;R.sub.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or a bivalent radical --CH.dbd.CH--CH.dbd.CH-- or --(CH.sub.2).sub.n --, where n is an integer from 3 to 5, inclusive, and the free bonds of said bivalent radical are attached to adjacent carbon atoms of the phenyl ring; andR.sub.3 is hydrogen or alkyl of 1 to 3 carbon atoms;R.sub.4 is alkyl of 1 to 3 carbon atoms; orR.sub.3 and R.sub.4, together with each other, are --(CH.sub.2).sub.p --, where p is an integer from 4 to 6, inclusive,or a non-toxic, pharmacologically acceptable acid addition salt thereof. The compounds of formula I are useful for treatment and prophylaxis of diseases of the coronaries, for the treatment of hypertension, and for treatment of cardiac arrhythmia, particularly tachycardia.
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