发明授权
US4620005A 1-isopropyl-4[(4-tetrahydro-1-naphthoyloxy
phenyl)(alkylene)-carbonyl(oxymethlcarbonyl)]piperazines having
chymotrypsin-inhibitory activity
失效
具有胰凝乳蛋白酶抑制活性的1-异丙基-4 [（4-四氢-1-萘氧基苯基）（亚烷基） - 羰基（羟甲羰基）]哌嗪
- 专利标题： 1-isopropyl-4[(4-tetrahydro-1-naphthoyloxy phenyl)(alkylene)-carbonyl(oxymethlcarbonyl)]piperazines having chymotrypsin-inhibitory activity
- 专利标题（中）： 具有胰凝乳蛋白酶抑制活性的1-异丙基-4 [（4-四氢-1-萘氧基苯基）（亚烷基） - 羰基（羟甲羰基）]哌嗪
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申请号： US787714申请日： 1985-10-17
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公开(公告)号： US4620005A公开(公告)日： 1986-10-28
- 发明人: Setsuro Fujii , Eizou Hattori , Mitsuteru Hirata , Hisashi Kunieda , Koichiro Watanabe , Hiroshi Ishihama
- 申请人： Setsuro Fujii , Eizou Hattori , Mitsuteru Hirata , Hisashi Kunieda , Koichiro Watanabe , Hiroshi Ishihama
- 申请人地址： JPX Nagoya
- 专利权人： Kowa Co., Ltd.
- 当前专利权人： Kowa Co., Ltd.
- 当前专利权人地址： JPX Nagoya
- 优先权： JPX58-98713 19830602
- 主分类号： C07D295/10
- IPC分类号： C07D295/10 ; A61K31/495 ; A61P1/00 ; A61P43/00 ; C07D295/108 ; C07D295/12 ; C07D295/13 ; C07D295/18 ; C07D295/185 ; C07D241/04
摘要：
Phenyl tetrahydronaphthylcarboxylate of the formula: ##STR1## wherein A is a direct bond, or a lower alkylene, vinylene or imino group; B is a direct bond, a lower alkylene or --NH-lower alkylene group, or an --OCH.sub.2 CO-- residual group; and R is a lower alkyl group, with the proviso that A and B are not direct bonds simultaneously, and A, B and R are not a lower alkylene group, a direct bond and a methyl group, respectively, at the same time, are effectively useful as chymotrypsin inhibitors.
公开/授权文献
- USPP4233P Peony plant named My Pal Rudy 公开/授权日：1978-04-04
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