公开(公告)号：US4620005A

公开(公告)日：1986-10-28

申请号：US787714

申请日：1985-10-17

申请人： Setsuro Fujii ,  Eizou Hattori ,  Mitsuteru Hirata ,  Hisashi Kunieda ,  Koichiro Watanabe ,  Hiroshi Ishihama

发明人： Setsuro Fujii ,  Eizou Hattori ,  Mitsuteru Hirata ,  Hisashi Kunieda ,  Koichiro Watanabe ,  Hiroshi Ishihama

IPC分类号： C07D295/10 ,  A61K31/495 ,  A61P1/00 ,  A61P43/00 ,  C07D295/108 ,  C07D295/12 ,  C07D295/13 ,  C07D295/18 ,  C07D295/185 ,  C07D241/04

CPC分类号： C07D295/185 ,  C07D295/108 ,  C07D295/13

摘要： Phenyl tetrahydronaphthylcarboxylate of the formula: ##STR1## wherein A is a direct bond, or a lower alkylene, vinylene or imino group; B is a direct bond, a lower alkylene or --NH-lower alkylene group, or an --OCH.sub.2 CO-- residual group; and R is a lower alkyl group, with the proviso that A and B are not direct bonds simultaneously, and A, B and R are not a lower alkylene group, a direct bond and a methyl group, respectively, at the same time, are effectively useful as chymotrypsin inhibitors.

摘要翻译： 下式的四氢萘基羧酸苯酯：其中A是直接键，或低级亚烷基，亚乙烯基或亚氨基; B是直接键，低级亚烷基或-NH-低级亚烷基或-OCH 2 CO-残基; 并且R是低级烷基，条件是A和B不是同时是直接键，并且A，B和R不分别是低级亚烷基，直接键和甲基，同时是 有效用作糜蛋白酶抑制剂。

公开(公告)号：US4605739A

公开(公告)日：1986-08-12

申请号：US608957

申请日：1984-05-10

申请人： Setsuro Fujii ,  Eizou Hattori ,  Mitsuteru Hirata ,  Hisashi Kunieda ,  Koichiro Watanabe ,  Hiroshi Ishihama

发明人： Setsuro Fujii ,  Eizou Hattori ,  Mitsuteru Hirata ,  Hisashi Kunieda ,  Koichiro Watanabe ,  Hiroshi Ishihama

IPC分类号： A61K31/495 ,  A61P1/00 ,  C07D207/12 ,  C07D209/42 ,  C07D403/12

CPC分类号： C07D209/42 ,  C07D207/12

摘要： Benzoyl indolecarboxylates of the formula: ##STR1## where R.sup.1 is hydrogen, halogen, lower alkyl or lower alkoxy; R.sup.2 is hydrogen, lower alkyl, acetyl or benzoyl; R.sup.3 is hydrogen or lower alkyl; and A is a direct bond, or lower alkylene or vinylene substituted at the 2-, 3- or 5-position of the indole nucleus, are effective agents as chymotrypsin inhibitors.

摘要翻译： 下式的苯甲酰基吲哚羧酸盐：其中R 1是氢，卤素，低级烷基或低级烷氧基; R2是氢，低级烷基，乙酰基或苯甲酰基; R3是氢或低级烷基; 并且A是直接键合，或在吲哚核的2-，3-或5-位取代的低级亚烷基或亚乙烯基，作为糜蛋白酶抑制剂是有效的试剂。

公开(公告)号：US4216225A

公开(公告)日：1980-08-05

申请号：US906567

申请日：1978-05-16

申请人： Masami Shiratsuchi ,  Kiyoshi Kawamura ,  Hisashi Kunieda ,  Naoki Machida ,  Toshihiro Akashi ,  Masahiko Nagakura

发明人： Masami Shiratsuchi ,  Kiyoshi Kawamura ,  Hisashi Kunieda ,  Naoki Machida ,  Toshihiro Akashi ,  Masahiko Nagakura

IPC分类号： A61K31/195 ,  A61K31/16 ,  A61K31/22 ,  A61P1/04 ,  C07C67/00 ,  C07C325/00 ,  C07C381/12 ,  C07D213/82 ,  A61K31/55 ,  A61K31/215

CPC分类号： C07D213/82

摘要： Methylmethioninesulfonium compounds of the formula ##STR1## wherein X.crclbar. represents an anion;R.sup.1 represents a hydrogen atom or an acyl group of the formula -COR.sup.3 in which R.sup.3 represents an alkyl group with 1 to 20 carbon atoms, the group --CH.sub.2).sub.2 COOH or the group ##STR2## in which Z represents a direct bond or a methylene or vinylene linkage, Y represents C or N, R.sup.4 represents a member selected from the class consisting of a hydrogen atom, lower alkyl groups, lower alkoxy groups, di-lower-alkylamino groups and a sulfamoyl group, n is a number of 1 to 3, and two or more R.sup.4 groups may be identical or different; andR.sup.2 represents the group --COOR.sup.5 in which R.sup.5 represents a hydrogen atom, an alkyl group with 1 to 5 carbon atoms or a metal- or metal complex-forming moiety, or the group ##STR3## in which R.sup.6 groups may be identical or different, and each represent a hydrogen atom or an alkyl group with 1 to 5 carbon atoms, with the proviso that when R.sup.1 represents a hydrogen atom, R.sup.2 is not --COOH; when R.sup.1 represents a hydrogen atom and R.sup.2 represents --CONH.sub.2, X.crclbar. is not Cl.crclbar.; and when R.sup.1 is --COCH.sub.3 and R.sup.2 is --COOCH.sub.3, X.crclbar. is not I.crclbar..The compounds can be easily prepared from methionine as a starting material by a combination of known unit reactions such as methylsulfonium-forming reaction, acylation, amidation, esterification and metal salt-forming reaction. These compounds are especially useful for treating ulcers.

摘要翻译： 其中X（ - ）表示阴离子的式“IMAGE”的甲基甲硫氨onium化合物; R 1表示氢原子或式-COR 3的酰基，其中R 3表示具有1至20个碳原子的烷基，基团-CH 2）2 COOH或其中Z表示直接键或基团 亚甲基或亚乙烯基，Y表示C或N，R4表示选自氢原子，低级烷基，低级烷氧基，二低级烷基氨基和氨磺酰基的成员，n为1 至3个，并且两个或更多个R 4基团可以相同或不同; 并且R 2表示其中R 5表示氢原子，具有1至5个碳原子的烷基或金属或金属络合物形成部分的基团-COOR 5或其中R6基团可以相同或不同的基团 并且各自表示氢原子或具有1至5个碳原子的烷基，条件是当R 1表示氢原子时，R 2不是-COOH; 当R 1表示氢原子且R 2表示-CONH 2时，X（ - ）不是Cl（ - ）; 当R1是-COCH3且R2是-COOCH3时，X（ - ）不是I（ - ）。 通过已知的单元反应如甲基锍形成反应，酰化，酰胺化，酯化和金属盐形成反应的组合，可以容易地从甲硫氨酸作为原料制备化合物。 这些化合物特别适用于治疗溃疡。

公开(公告)号：US07281019B2

公开(公告)日：2007-10-09

申请号：US10255570

申请日：2002-09-26

申请人： Masakatsu Taketa ,  Kaori Arihiro ,  Hiroshi Ishizaki ,  Hisashi Kunieda ,  Tsutomu Munemoto ,  Masayuki Kamiya ,  Yoshiki Hayashi

发明人： Masakatsu Taketa ,  Kaori Arihiro ,  Hiroshi Ishizaki ,  Hisashi Kunieda ,  Tsutomu Munemoto ,  Masayuki Kamiya ,  Yoshiki Hayashi

IPC分类号： G06F7/00

CPC分类号： G06Q10/10 ,  Y10S707/99931 ,  Y10S707/99935 ,  Y10S707/99945

摘要： A case management method that reduces the number of manual operations, prevents manual errors, guarantees updated data, and enables knowledge of the present location of a storage file. In the case management method, case information involving a processing deadline is input to the management computer. At least one event, which is a task including a single operation and involving the processing deadline or a task including a series of operations and involving the processing deadline, is generated. Workflows, which are series of operations performed in a section that is determined beforehand in accordance with the type of generated event, are stored in a database. A predetermined workflow is selected from the stored workflow. An event pool storing the generated event in association with the selected predetermined workflow is generated in the database.

摘要翻译： 减少手动操作次数的案例管理方法，防止手动错误，保证更新的数据，以及对存储文件的当前位置的了解。 在案件管理方法中，将涉及处理期限的案件信息输入到管理计算机。 生成至少一个事件，其是包括单个操作并涉及处理期限的任务或包括一系列操作并涉及处理截止期限的任务。 在根据生成的事件的类型预先确定的部分中执行的一系列操作的工作流被存储在数据库中。 从存储的工作流中选择预定的工作流程。 在数据库中生成存储与选择的预定工作流相关联的生成事件的事件池。

公开(公告)号：US4394382A

公开(公告)日：1983-07-19

申请号：US271927

申请日：1981-06-09

申请人： Masami Shiratsuchi ,  Noboru Shimizu ,  Hiromichi Shigyo ,  Yoshinori Kyotani ,  Hisashi Kunieda ,  Kiyoshi Kawamura ,  Seiichi Sato ,  Toshihiro Akashi ,  Masahiko Nagakura ,  Naotoshi Sawada ,  Yasumi Uchida

发明人： Masami Shiratsuchi ,  Noboru Shimizu ,  Hiromichi Shigyo ,  Yoshinori Kyotani ,  Hisashi Kunieda ,  Kiyoshi Kawamura ,  Seiichi Sato ,  Toshihiro Akashi ,  Masahiko Nagakura ,  Naotoshi Sawada ,  Yasumi Uchida

IPC分类号： C07D311/04 ,  A61K31/353 ,  A61P9/02 ,  A61P9/04 ,  A61P21/02 ,  C07D311/22 ,  C07D311/58 ,  C07D311/64 ,  C07D311/66 ,  A61K31/35

CPC分类号： C07D311/22 ,  C07D311/58 ,  C07D311/64 ,  C07D311/66 ,  Y10S514/821

摘要： A benzopyran compound represented by the following ##STR1## wherein A represents a direct bond or the bond --CH.sub.2 --O--,R.sub.1 represents a member selected from the group consisting of a C.sub.3 -C.sub.5 alkyl group, a hydroxy-(C.sub.3 -C.sub.5 alkyl) group, a lower alkylamino-lower alkyl group, a nitrato-(C.sub.3 -C.sub.5 alkyl) group and a phenyl-(C.sub.1 -C.sub.5) alkyl group, provided that the phenyl may be substituted by a lower alkoxy group, R.sub.2 represents a member selected from the group consisting of hydrogen, halogen, OH, NO.sub.2, a carbamoyl group, a lower alkyl group, a lower alkoxy group, a lower alkyleneoxy group and acetyl group,R.sub.3 represents hydrogen or NO.sub.2,B represents a direct bond, a C.sub.1 -C.sub.7 alkylene group, a --O-lower alkylene group or a --CONH-lower alkylene group, andn represents 1 or 2;and an acid addition salt thereof and a pharmaceutical composition comprising aforesaid compound.

摘要翻译： 由下式（I）表示的苯并吡喃化合物，其中A表示直接键或键-CH2-O-，R1表示选自C3-C5烷基，羟基 - （C3 -C 5烷基）基，低级烷基氨基 - 低级烷基，硝基 - （C 3 -C 5烷基）基和苯基 - （C 1 -C 5）烷基，条件是苯基可以被低级烷氧基取代，R 2 表示选自氢，卤素，OH，NO 2，氨基甲酰基，低级烷基，低级烷氧基，低级亚烷基氧基和乙酰基的成员，R 3表示氢或NO 2，B表示直接键 ，C 1 -C 7亚烷基，-O-低级亚烷基或-CONH-低级亚烷基，n表示1或2; 及其酸加成盐和包含上述化合物的药物组合物。

公开(公告)号：US4482562A

公开(公告)日：1984-11-13

申请号：US414819

申请日：1982-09-03

申请人： Masami Shiratsuchi ,  Noboru Shimizu ,  Hiromichi Shigyo ,  Yoshinori Kyotani ,  Hisashi Kunieda ,  Kiyoshi Kawamura ,  Seiichi Sato ,  Toshihiro Akashi ,  Masahiko Nagakura ,  Naotoshi Sawada ,  Yasumi Uchida

发明人： Masami Shiratsuchi ,  Noboru Shimizu ,  Hiromichi Shigyo ,  Yoshinori Kyotani ,  Hisashi Kunieda ,  Kiyoshi Kawamura ,  Seiichi Sato ,  Toshihiro Akashi ,  Masahiko Nagakura ,  Naotoshi Sawada ,  Yasumi Uchida

IPC分类号： A61K31/21 ,  A61K31/135 ,  A61K31/165 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4418 ,  A61P9/00 ,  A61P9/12 ,  A61P25/02 ,  A61P25/28 ,  C07C67/00 ,  C07C203/04 ,  C07C213/00 ,  C07C217/32 ,  C07C217/70 ,  C07C219/16 ,  C07C219/34 ,  C07C225/16 ,  C07C231/00 ,  C07C231/12 ,  C07C235/42 ,  C07C235/46 ,  C07C237/30 ,  C07C301/00 ,  C07C303/40 ,  C07C311/17 ,  C07C311/29 ,  C07C313/00 ,  C07C315/04 ,  C07C317/22 ,  C07C317/24 ,  C07C317/32 ,  C07C319/20 ,  C07C323/25 ,  C07D213/30 ,  C07D213/60 ,  C07D213/64 ,  C07D213/69 ,  C07D303/24 ,  C07D303/26 ,  C07D309/12 ,  C07D213/74

CPC分类号： C07D213/64 ,  C07C203/04 ,  C07D213/69 ,  C07D303/24 ,  C07D303/26 ,  C07D309/12

摘要： A compound represented by the following formula ##STR1## wherein A represents a direct bond or the bond --O--CH.sub.2 --,B represents a C.sub.1 -C.sub.11 alkylene group bonded to a carbon atom of the aromatic ring D either directly or through --O--, --S--, --SO-- or --NH--,W represents a carbon or nitrogen atom,R.sub.1 represents a C.sub.3 -C.sub.7 alkyl group, a hydroxy-C.sub.1 -C.sub.6 alkyl group, or a phenyl- or diphenyl-alkyl group with the alkyl group having 1 to 4 carbon atoms,R.sub.2 represents a member selected from the group consisting of hydrogen, halogen, OH, C.sub.1 -C.sub.4 alkyl, NO.sub.2, C.sub.1 -C.sub.4 alkoxy, acetyl, allyloxy, carbamoyl and sulfamoyl, and when two or more R.sub.2 groups exist, they may be identical or different, andn represents 1, 2 or 3 and m represents 1 or 2, provided that n+m.gtoreq.4;and an acid addition salt thereof; a process for producing the same; and a pharmaceutical composition comprising aforesaid compound.

公开(公告)号：US4374840A

公开(公告)日：1983-02-22

申请号：US233643

申请日：1981-02-11

申请人： Masami Shiratsuchi ,  Noboru Shimizu ,  Hiromichi Shigyo ,  Yoshinori Kyotani ,  Hisashi Kunieda ,  Kiyoshi Kawamura ,  Seiichi Sato ,  Toshihiro Akashi ,  Masahiko Nagakura ,  Naotoshi Sawada ,  Yasumi Uchida

发明人： Masami Shiratsuchi ,  Noboru Shimizu ,  Hiromichi Shigyo ,  Yoshinori Kyotani ,  Hisashi Kunieda ,  Kiyoshi Kawamura ,  Seiichi Sato ,  Toshihiro Akashi ,  Masahiko Nagakura ,  Naotoshi Sawada ,  Yasumi Uchida

IPC分类号： A61K31/21 ,  A61K31/135 ,  A61K31/165 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4418 ,  A61P9/00 ,  A61P9/12 ,  A61P25/02 ,  A61P25/28 ,  C07C67/00 ,  C07C203/04 ,  C07C213/00 ,  C07C217/32 ,  C07C217/70 ,  C07C219/16 ,  C07C219/34 ,  C07C225/16 ,  C07C231/00 ,  C07C231/12 ,  C07C235/42 ,  C07C235/46 ,  C07C237/30 ,  C07C301/00 ,  C07C303/40 ,  C07C311/17 ,  C07C311/29 ,  C07C313/00 ,  C07C315/04 ,  C07C317/22 ,  C07C317/24 ,  C07C317/32 ,  C07C319/20 ,  C07C323/25 ,  C07D213/30 ,  C07D213/60 ,  C07D213/64 ,  C07D213/69 ,  C07D303/24 ,  C07D303/26 ,  C07D309/12 ,  C07D213/74

CPC分类号： C07D213/64 ,  C07C203/04 ,  C07D213/69 ,  C07D303/24 ,  C07D303/26 ,  C07D309/12

摘要： A compound represented by the following formula ##STR1## wherein A represents a direct bond or the bond --0--CH.sub.2--,B represents a C.sub.1 -C.sub.11 alkylene group bonded to a carbon atom of the aromatic ring D either directly or through --O--, --S--, --SO-- or --NH--,W represents a carbon or nitrogen atom,R.sub.1 represents a C.sub.3 -C.sub.7 alkyl group, a hydroxy-C.sub.1 -C.sub.6 alkyl group, or a phenyl- or diphenyl-alkyl group with the alkyl group having 1 to 4 carbon atoms,R.sub.2 represents a member selected from the group consisting of hydrogen, halogen, OH, C.sub.1 -C.sub.4 alkyl, NO.sub.2, C.sub.1 -C.sub.4 alkoxy, acetyl, allyloxy, carbamoyl and sulfamoyl, and when two or more R.sub.2 groups exist, they may be identical or different, andn represents 1, 2 or 3 and m represents 1 or 2, provided that n+m.gtoreq.4;and an acid addition salt thereof; a process for producing the same; and a pharmaceutical composition comprising aforesaid compound.

摘要翻译： 由下式表示的化合物：其中A表示直接键或-O-CH 2 - 键，B表示与芳环D的碳原子键合的C1-C11亚烷基直接或-O- ，-S-，-SO-或-NH-，W表示碳原子或氮原子，R1表示C3-C7烷基，羟基-C1-C6烷基或苯基或二苯基 - 烷基，其中 具有1至4个碳原子的烷基，R 2表示选自氢，卤素，OH，C 1 -C 4烷基，NO 2，C 1 -C 4烷氧基，乙酰基，烯丙氧基，氨基甲酰基和氨磺酰基的成员，当两个或更多个 R2基团存在，它们可以相同或不同，n表示1,2或3，m表示1或2，条件是n + m> = 4; 及其酸加成盐; 其制造方法; 和包含上述化合物的药物组合物。

公开(公告)号：US4290954A

公开(公告)日：1981-09-22

申请号：US89403

申请日：1979-10-30

申请人： Kazuhiro Onogi ,  Hisashi Kunieda ,  Kiyoshi Kawamura ,  Masami Shiratsuchi ,  Masahiko Nagakura ,  Naoki Machida, deceased ,  by Takayasu Miwa, heir

发明人： Kazuhiro Onogi ,  Hisashi Kunieda ,  Kiyoshi Kawamura ,  Masami Shiratsuchi ,  Masahiko Nagakura ,  Naoki Machida, deceased ,  by Takayasu Miwa, heir

IPC分类号： A61K31/35 ,  A61K31/352 ,  A61K31/41 ,  A61K31/495 ,  A61K31/535 ,  A61P25/04 ,  A61P29/00 ,  A61P37/08 ,  C07D311/86 ,  C07D405/04 ,  C07D405/12 ,  C07D405/10 ,  C07D413/10

CPC分类号： C07D311/86

摘要： A tetrahydroxanthone derivative represented by the general formula: ##STR1## wherein R is a hydrogen atom, a hydroxyl, cyano, lower alkyl, lower alkoxy, lower acyloxy, benzoyloxy or tetrazolyl group, or ##STR2## (R.sub.3 is a hydrogen atom, R.sub.4 is a hydrogen atom, a phenyl group which may be optionally substituted, or a tetrazolyl group; or R.sub.3 and R.sub.4 commonly form a ring together with the adjacent nitrogen atom and another nitrogen atom or an oxygen atom); R.sub.1 is a hydrogen or halogen atom, a lower alkyl, cyano, carboxyl or tetrazolyl group, or ##STR3## (R.sub.5 is a hydrogen atom, R.sub.6 is a phenyl group which may be optionally substituted, or a tetrazolyl group; or R.sub.5 and R.sub.6 commonly form a ring together with the adjacent nitrogen atom and an oxygen atom); and R.sub.2 is a hydrogen or halogen atom, or a lower alkyl group; with the proviso that neither R nor R.sub.1 is a hydrogen atom; when R is --CONH.sub.2, R.sub.1 and R.sub.2 are not respectively a hydrogen atom nor a hydrogen or halogen atom, or a lower alkyl group; and R.sub.2 and R.sub.1 are not respectively a hydrogen atom nor a halogen atom or a lower alkyl group. Exhibits anti-allergic, anti-inflammatory, analgesic, inhibitory and asthma-treating activities.

摘要翻译： 其中R是氢原子，羟基，氰基，低级烷基，低级烷氧基，低级酰氧基，苯甲酰氧基或四唑基，或者是（R 3是氢原子，R 4 是氢原子，可以被任意取代的苯基或四唑基;或者R3和R4通常与相邻的氮原子和另一个氮原子或氧原子一起形成环）; R 1是氢或卤素原子，低级烷基，氰基，羧基或四唑基，或者R 5是氢原子，R 6是任选被取代的苯基或四唑基;或R 5和R 6 通常与相邻的氮原子和氧原子一起形成环）; 并且R 2是氢或卤原子或低级烷基; 条件是R和R1都不是氢原子; 当R为-CONH 2时，R 1和R 2不分别为氢原子或氢或卤素原子或低级烷基; R2和R1不分别为氢原子或卤素原子或低级烷基。 展示抗过敏，抗炎，镇痛，抑制和哮喘治疗活动。