发明授权
- 专利标题: Naphtho(1,8-bc)-1,5-thiazocinones
- 专利标题(中): 萘酚(1,8-bc)-1,5-噻唑酮
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申请号: US843317申请日: 1986-03-24
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公开(公告)号: US4640930A公开(公告)日: 1987-02-03
- 发明人: Erno Mohacsi , Jay P. O'Brien
- 申请人: Erno Mohacsi , Jay P. O'Brien
- 申请人地址: NJ Nutley
- 专利权人: Hoffmann-La Roche Inc.
- 当前专利权人: Hoffmann-La Roche Inc.
- 当前专利权人地址: NJ Nutley
- 主分类号: A61K31/395
- IPC分类号: A61K31/395 ; A61K31/40 ; A61K31/445 ; A61P3/00 ; A61P3/14 ; A61P9/00 ; A61P9/10 ; A61P9/12 ; C07D281/18 ; A61K31/55
摘要:
A compound of the formula ##STR1## wherein R.sub.1 is phenyl substituted with 1 to 3 lower alkoxy groups, or 1 to 3 halogens; R.sub.2 is hydroxy or lower alkanoyloxy; R.sub.3 and R.sub.4 are each independently lower alkyl or together form a pyrrolidine or piperidine ring; and n is 2 to 4, and pharmaceutically acceptable acid addition salts thereof are described. The compounds of formula I are active as calcium channel blockers and accordingly, are useful as agents for lowering blood pressure, and as agents for treating ischemia.
公开/授权文献
- US5761920A Ice detection in ice making apparatus 公开/授权日:1998-06-09
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