A method of beneficiation of complex sulfide ores comprises crushing and grinding complex sulfide ore containing sulfides of copper, zinc, iron and other minerals, subjecting the ground ores to differential flotation to obtain a bulk copper-zinc concentrate which is separate from pyrite and gangue, and passing the bulk copper-zinc concentrate through a high-gradient magnetic separator having an open-bore magnetic field filled with a matrix element, so as to recover separately a magnetic copper concentrate and a non-magnetic zinc concentrate. By combining the differential flotation with high-gradient magnetic separation, the present invention enables individual separation of copper and zinc concentrates without using many reagents in high volumes and by a simple process control.