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公开(公告)号：US11130141B2
公开(公告)日：2021-09-28
申请号：US16327313
申请日：2017-08-21
申请人： Thomas A Valerio
发明人： Thomas A Valerio
摘要： Devices, systems, and methods for separating waste stream with high glass concentrations to recover desired materials are described. The devices, systems, and methods may include a wet separator, a multi-stage screen(s), shredder(s), rising velocity separator(s)/jig(s), magnetic pulley(s), eddy current separator(s), and/or optical sorters.
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公开(公告)号：US09968943B2
公开(公告)日：2018-05-15
申请号：US15199842
申请日：2016-06-30
发明人： Saud A. Khashan
CPC分类号： B01L3/502761 , B01L3/502776 , B01L2200/0652 , B01L2300/0816 , B01L2400/043 , B03C1/01 , B03C1/288 , B03C2201/18 , B03C2201/26
摘要： The magnetic particle separator uses an induced magnetic field to separate magnetic particles held in solution by magnetophoresis. The magnetic particles may be, for example, inherently paramagnetic or superparamagnetic, may be magnetically tagged or the like. First and second magnetic particles initially flow along a longitudinal direction. An external magnetic field along a lateral direction, orthogonal (or near orthogonal) to the longitudinal direction, is applied to an externally magnetizable wire, which extends along a transverse direction orthogonal to both the longitudinal and lateral directions. The external magnetic field generates an induced magnetic field in the externally magnetizable wire, and the induced magnetic field generates repulsive magnetic force on the first and second magnetic particles. Due to differing magnetic susceptibility, size and/or mass between the first and second magnetic particles, they are separated by following separate paths generated by the respective magnetic forces thereon.
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3.发明申请SYSTEM AND METHOD FOR BIOLOGICAL APPLICATIONS USING PRE-DETERMINED SIZED NANOPARTICLES 有权使用预先确定的尺寸纳米颗粒的生物应用的系统和方法公开(公告)号：US20170071535A1
公开(公告)日：2017-03-16
申请号：US15342262
申请日：2016-11-03
发明人： Ronald D. Weiss
CPC分类号： A61B5/4839 , A61B5/0035 , A61B5/0515 , A61B5/055 , A61B5/7246 , A61B2562/0285 , A61K49/0002 , A61K49/1818 , B03C1/025 , B03C1/30 , B03C2201/18 , B03C2201/26
摘要： The invention features an apparatus for producing a fluid stream having plurality of nanoparticles in the fluid stream. The apparatus includes a source configured to provide a fluid stream having a first randomly sized distribution of a plurality of nanoparticles; a flow control zone configured to receive the fluid stream from the source and to control the fluid stream to produce a controlled fluid stream having a selected flow rate; a separation zone configured to receive and to separate the selectively controlled fluid stream into at least one separated fluid stream having a non-randomly sized distribution of nanoparticles; and a collection zone capable of receiving the separated fluid stream according to at least one non-random sized distribution of nanoparticles to produce at least one collected stream. The apparatus is configured for a continuous flow of the fluid stream. A size of a nanoparticle can be related to an intrinsic core diameter, a hydrodynamic diameter, and a combination of intrinsic core diameter and hydrodynamic diameter measurements. The nanoparticles can include non-magnetic nanoparticles, partially magnetic nanoparticles, magnetic nanoparticles, superparamagnetic nanoparticles, and a combination of at least two different nanoparticle types. The invention also features methods for producing said fluid streams. The invention further features apparatus and methods for cancer confirmation and targeted therapeutic drug development.
摘要翻译： 本发明的特征在于一种用于在流体流中产生具有多个纳米颗粒的流体流的装置。 该装置包括：源，其配置成提供具有多个纳米颗粒的第一随机大小分布的流体流; 流动控制区域，其被配置为从所述源接收流体流并且控制所述流体流以产生具有选定流量的受控流体流; 分离区，被配置为接收并且将选择性控制的流体流分离成具有非随机大小的纳米颗粒分布的至少一个分离的流体流; 以及能够根据至少一个非随机大小的纳米颗粒分布接收分离的流体流以产生至少一个收集的流的收集区。 该装置构造成用于流体流的连续流动。 纳米颗粒的尺寸可以与本征芯直径，流体动力学直径以及本征芯直径和流体动力学直径测量的组合有关。 纳米颗粒可以包括非磁性纳米颗粒，部分磁性纳米颗粒，磁性纳米颗粒，超顺磁性纳米颗粒，以及至少两种不同纳米颗粒类型的组合。 本发明还涉及生产所述流体流的方法。 本发明还涉及用于癌症确认和靶向治疗药物开发的装置和方法。
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4.发明授权公开(公告)号：US09592467B2
公开(公告)日：2017-03-14
申请号：US14228924
申请日：2014-03-28
IPC分类号： B01D21/00 , B01D49/00 , B03C1/00 , B03C1/02 , B03C1/025 , B03C1/031 , B03C1/033 , B03C1/28 , C09F1/00 , B03C1/035 , C08F8/04
CPC分类号： B01D49/00 , B01D21/0009 , B03C1/035 , B03C1/286 , B03C2201/18 , C08F8/04
摘要： Fouling rate inhibition for a hydrogenation reactor. A hydrocarbon hydrogenation method comprises passing a liquid feedstream through a magnetic field to separate magnetically susceptible particles, and introducing the magnetically lean stream into a fixed catalyst bed under hydrogenation conditions to saturate carbon-carbon double bonds in the hydrocarbon. Also, a hydrogenation reactor system comprises a magnetic conditioning zone, an inlet flow path to introduce a magnetically lean stream from the magnetic conditioning zone into a fixed catalyst bed and an outlet flow path from an outlet end of the catalyst bed to withdraw reactor effluent.
摘要翻译： 氢化反应器的结垢速率抑制。 烃氢化方法包括使液体进料流通过磁场分离磁性敏感颗粒，并将氢稀释流引入固定的催化剂床中，使氢化条件下的碳 - 碳双键饱和。 此外，氢化反应器系统包括磁调节区，入口流动路径，用于将来自磁调节区的磁性稀薄流引入固定的催化剂床和从催化剂床的出口端排出反应器流出物的出口流动路径。
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公开(公告)号：US20140367312A1
公开(公告)日：2014-12-18
申请号：US14355996
申请日：2012-08-06
CPC分类号： B03C1/025 , B03C1/002 , B03C1/0335 , B03C1/035 , B03C1/26 , B03C2201/20
摘要： The present disclosure provides an apparatus for sorting a particulate material. The apparatus comprises a receiving portion for receiving the particulate material having a particle size within a predetermined range of sizes. The apparatus also comprises a distributor for receiving the particulate material at an upper end thereof and having a sloped distribution surface along which, in use, the particulate material passes substantially by gravity. A surface area of the sloped distribution surface increases towards a lower end of the distributor to facilitate a monolayer feed stream of the particles exiting and falling from a lower end of the distributor distributed as a curtain-like stream of particles. The apparatus further comprises a magnetic element for generating a magnetic force that is directed such that the particles of the falling feed stream that exit the lower end of the distributor have pathways that depend on magnetic properties of the particles. The apparatus also comprises sorting portions for sorting the particles based on the pathways of the particles.
摘要翻译： 本公开提供了一种用于分选颗粒材料的设备。 该装置包括用于接收具有在预定尺寸范围内的粒度的颗粒材料的接收部分。 该设备还包括用于在其上端处接收颗粒材料并具有倾斜分布表面的分配器，在使用中，颗粒材料沿着该倾斜分布表面基本上通过重力通过。 倾斜分布表面的表面积朝向分配器的下端增加，以促进颗粒的单层进料流从分配器的下端排出并且作为帷幕状的颗粒分布分布。 该装置还包括用于产生磁力的磁性元件，该磁力被定向成使得离开分配器的下端的下降的进料流的颗粒具有取决于颗粒的磁性的通路。 该装置还包括基于颗粒的路径分选颗粒的分选部分。
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公开(公告)号：US20110132810A1
公开(公告)日：2011-06-09
申请号：US12964567
申请日：2010-12-09
CPC分类号： B03C1/0335 , B03C1/005 , B03C1/035 , B03C2201/20
摘要： A process of sorting metallic single wall carbon nanotubes (SWNTs) from semiconducting types by disposing the SWNTs in a dilute fluid, exposing the SWNTs to a dipole-inducing magnetic field which induces magnetic dipoles in the SWNTs so that a strength of a dipole depends on a conductivity of the SWNT containing the dipole, orienting the metallic SWNTs, and exposing the SWNTs to a magnetic field with a spatial gradient so that the oriented metallic SWNTs drift in the magnetic field gradient and thereby becomes spatially separated from the semiconducting SWNTs. An apparatus for the process of sorting SWNTs is disclosed.
摘要翻译： 通过将SWNTs置于稀释流体中来分离来自半导体类型的金属单壁碳纳米管（SWNT）的过程，将SWNT暴露于偶极诱导磁场，其诱导SWNT中的磁偶极子，使得偶极子的强度取决于 包含偶极子的SWNT的导电性，定向金属SWNT，并将SWNT暴露于具有空间梯度的磁场，使得定向金属SWNT在磁场梯度中漂移，从而与半导体SWNT空间分离。 公开了一种用于排序SWNT的过程的设备。
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7.发明申请SEPARATOR COLUMN, SEPARATOR SYSTEM, METHOD OF FRACTIONATING MAGNETIC PARTICLES, METHOD OF MANUFACTURING A SEPARATOR COLUMN AND USE OF A SEPARATOR COLUMN 审中-公开分离器柱，分离器系统，分离磁性颗粒的方法，制造分离器柱的方法和分离器柱的使用公开(公告)号：US20100243574A1
公开(公告)日：2010-09-30
申请号：US12739177
申请日：2008-10-24
CPC分类号： B03C1/286 , A61B5/0515 , B03C1/01 , B03C1/0335 , B03C2201/18 , G01N30/0005
摘要： A separator system with a separator column and a method of fractionating magnetic particles, preferably using field-flow fractionation is proposed, which allows for more effective fractionation of magnetic particles with respect to their dynamic magnetic response in a wide frequency and amplitude range of an applied magnetic field, in particular relevant for magnetic particle imaging (MPI).
摘要翻译： 提出了一种具有隔离柱的分离器系统和优选使用场流分级分离磁性颗粒的方法，其允许在所施加的宽频率和振幅范围内相对于其动态磁响应更有效地分级磁性颗粒 磁场，特别是与磁性粒子成像（MPI）有关。
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公开(公告)号：US5993665A
公开(公告)日：1999-11-30
申请号：US867008
申请日：1997-06-02
IPC分类号： B03C1/025 , B01D35/06 , B03C1/034 , B03C1/035 , G01N33/533 , G01N33/543 , B01D35/00
CPC分类号： B03C1/025 , B01L3/502 , B03C1/034 , B03C1/035 , G01N27/745 , G01N33/54326 , G01N33/54366 , B01L2400/043 , Y10T436/108331 , Y10T436/25375
摘要： A method of quantitative analysis of microscopic biological specimens in a fluid medium is disclosed in which the specimens are rendered magnetically responsive by immunospecific binding with ferromagnetic colloid. A known quantity of magnetically-responsive marker particles are added to the fluid medium. The fluid medium is then subjected to a magnetic separation process, to collect the magnetic species from the fluid. The collected species are resuspended in a second fluid medium, and the relative quantities thereof are enumerated to determine the concentration of the desired biological specimen in the first fluid medium. The marker particles may comprise magnetic particles having a relatively large magnetic moment, a magnetic moment approximately equal to the magnetically-labelled biological speciment of interest, or both in order to compensate the determination for variations in immunospecific binding affinity and/or magnetic collection efficiency. The present method is useful for conducting hematological assays, such as red blood cell counts and related determinations. In the case of red blood cells, the specimens may be rendered magnetically responsive by reduction of the iron atoms present in hemoglobin. The enumeration step of the method may be conducted with such equipment as a flow cytometer, or by a novel optical scanning magnetic cell immobilization apparatus.
摘要翻译： 公开了一种流体介质中微观生物样本的定量分析方法，其中通过与铁磁性胶体的免疫特异性结合使样本呈现磁响应。 将已知量的磁响应标记颗粒添加到流体介质中。 然后对流体介质进行磁分离处理，以从流体中收集磁性物质。 将收集的物质重新悬浮在第二流体培养基中，并列举其相对量以确定第一流体培养基中所需生物样品的浓度。 标记颗粒可以包括具有相对大的磁矩，大约等于感兴趣的磁性标记的生物学物理学的磁矩或两者的磁性颗粒，以补偿免疫特异性结合亲和力和/或磁收集效率的变化的确定。 本方法可用于进行血液学测定，如红细胞计数和相关测定。 在红细胞的情况下，可以通过还原血红蛋白中存在的铁原子来使样品呈现磁响应性。 该方法的计数步骤可以用流式细胞仪等设备进行，也可以通过新的光学扫描磁性细胞固定装置进行。
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公开(公告)号：US5876593A
公开(公告)日：1999-03-02
申请号：US931067
申请日：1997-09-15
申请人： Paul A. Liberti , Yuzhou Wang
发明人： Paul A. Liberti , Yuzhou Wang
IPC分类号： B01D35/06 , B03C1/00 , B03C1/01 , B03C1/025 , B03C1/032 , B03C1/033 , B03C1/034 , B03C1/035 , B03C1/28 , C12M3/00 , G01N33/483 , G01N33/543 , G01N33/569 , G01N35/00 , G01N35/02
CPC分类号： B03C1/002 , B03C1/01 , B03C1/025 , B03C1/032 , B03C1/0332 , B03C1/034 , B03C1/035 , C12M47/04 , G01N33/54326 , G01N33/56972 , G01N35/026 , G01N2333/70589 , G01N35/0098 , Y10T436/108331 , Y10T436/25375
摘要： Biological entities such as cells, microbes, or components thereof are labeled with a magnetic colloid containing microscopic magnetic particles. The magnetic particles have a coating capable of biospecific or non-specific binding with the entities. An immobilization apparatus includes a non-magnetic vessel having a ferromagnetic collection structure for attracting the entities toward a collection surface upon which the magnetically labeled entities are immobilized subsequent to placement of the vessel on a support between two magnets. The ferromagnetic collection structure preferably has a sharp edge or high curvature for intensifying the magnetic field and for collecting the entities in a monolayer. The vessel includes an un-obstructed observation path so that immobilized entities may be observed and/or manipulated. The ferromagnetic collection structure may be arranged in various two dimensional patterns to provide a desired collection configuration. The apparatus may further have inlet and outlet ports for allowing a flow of liquid reagent through the vessel for washing or straining the immobilized entities. The support can be translated so that a shoulder on the collection structure concentrates the collected entities by movement of the shoulder in a transverse direction relative to the magnetic field.
摘要翻译： PCT No.PCT / US93 / 11087 Sec。 371日期1995年04月24日 102（e）1995年4月24日PCT PCT 1997年9月15日PCT公布。 公开号WO94 / 11078 日期1994年5月26日生物实体如细胞，微生物或其组分用含有微观磁性颗粒的磁性胶体标记。 磁性颗粒具有能够与实体进行生物特异性或非特异性结合的涂层。 固定装置包括具有铁磁收集结构的非磁性容器，用于在将容器放置在两个磁体之间的支撑件上时，将实体吸引到收集表面，在该收集表面上磁性标记的实体被固定。 铁磁收集结构优选地具有尖锐的边缘或高曲率，用于增强磁场和用于在单层中收集实体。 容器包括未阻挡的观察路径，使得可以观察和/或操纵固定的实体。 铁磁收集结构可以以各种二维图案布置以提供期望的收集配置。 该装置还可以具有用于允许液体试剂流过容器的入口和出口，用于洗涤或使固定的实体变窄。 支撑件可以平移，使得收集结构上的肩部通过肩部相对于磁场的横向方向的移动来集中收集的实体。
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10.发明授权
公开(公告)号：US5786040A
公开(公告)日：1998-07-28
申请号：US626082
申请日：1996-04-01
申请人： Johna Leddy , Sudath Amarasinghe
发明人： Johna Leddy , Sudath Amarasinghe
IPC分类号： B03C1/01 , B03C1/025 , B03C1/034 , B03C1/035 , C23C6/00 , C23C24/08 , C23C30/00 , C25B11/00 , C25D3/54 , G21F9/12 , H01F1/00 , H01F10/00 , H01F41/24 , H01F41/26 , H01F41/30 , H01M4/02 , H01M4/86 , H01M4/88 , H01M4/90 , H01M4/92 , H01M8/00 , H01M8/04 , H01M8/10 , H01M8/24 , H01M10/42 , B05D1/00
CPC分类号： H01M4/8857 , B03C1/01 , B03C1/025 , B03C1/034 , B03C1/035 , B82Y25/00 , B82Y40/00 , C23C24/08 , C23C30/00 , C23C6/00 , C25B11/00 , C25D3/54 , G21F9/12 , H01F1/0027 , H01F1/009 , H01F10/007 , H01F41/24 , H01F41/26 , H01F41/301 , H01M10/42 , H01M4/02 , H01M4/86 , H01M4/8605 , H01M4/9083 , H01M4/926 , H01M8/04223 , H01M8/1004 , H01M8/1009 , H01F1/0054 , H01M2300/0082 , H01M4/8882 , H01M8/249 , Y10T428/32
摘要： A method for coating a surface with a magnetic composite material exhibiting distinct flux properties due to gradient interfaces within the composite. Surfaces coated with such a composite can be used to improve fuel cells and to effect improved transport and separation of different species of materials. A wide variety of devices can incorporate such composite-coated surfaces, including separators, fuel cells, electrochemical cells, and electrodes for channeling flux of, or for effecting electrolysis of, magnetic species.
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