发明授权
US4703048A Novel 1-benzhydryl-4-cinnamylpiperazine derivatives, and pharmaceutical
compositions comprising said compounds as active ingredient for
treating a cerebrovascular disease
失效
新型的1-二苯甲基-4-肉桂基哌嗪衍生物和包含所述化合物作为治疗脑血管疾病的活性成分的药物组合物
- 专利标题： Novel 1-benzhydryl-4-cinnamylpiperazine derivatives, and pharmaceutical compositions comprising said compounds as active ingredient for treating a cerebrovascular disease
- 专利标题（中）： 新型的1-二苯甲基-4-肉桂基哌嗪衍生物和包含所述化合物作为治疗脑血管疾病的活性成分的药物组合物
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申请号： US815452申请日： 1985-12-31
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公开(公告)号： US4703048A公开(公告)日： 1987-10-27
- 发明人: Hiroshi Ohtaka , Toshiro Kanazawa , Keizo Ito , Goro Tsukamoto
- 申请人： Hiroshi Ohtaka , Toshiro Kanazawa , Keizo Ito , Goro Tsukamoto
- 申请人地址： JPX Tokyo
- 专利权人： Kanebo Ltd.
- 当前专利权人： Kanebo Ltd.
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX60-3696 19850111
- 主分类号： C07D295/08
- IPC分类号： C07D295/08 ; A61K31/495 ; A61P9/00 ; C07D295/096
摘要：
A 1-benzhydryl-4-cinnamylpiperazine derivative represented by the following formula (I) ##STR1## wherein R.sup.1 represents a hydrogen atom or a methoxy group, and R.sup.2 represents a hydrogen or fluorine atom, or a pharmaceutically acceptable acid addition salt thereof. The compound (I) is prepared by selectively reducing the corresponding 1-benzhydryl-4-cinnamoylpiperazine derivative and optionally converting the product into its acid addition salt. The compound (I) is useful for treatment of cerebrovascular disease in a human.
公开/授权文献
- US5872025A Method for stacked three dimensional device manufacture 公开/授权日：1999-02-16
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