Invention Grant
US4743613A Ester prodrugs of dopamine-.beta.-hydroxylase, inhibitors, composition
containing them, and method of using them to inhibit
dopamine-.beta.-hydroxylase activity
失效
多巴胺-β-羟化酶的酯前体药物，抑制剂，含有它们的组合物以及使用它们抑制多巴胺-β-羟化酶活性的方法
- Patent Title: Ester prodrugs of dopamine-.beta.-hydroxylase, inhibitors, composition containing them, and method of using them to inhibit dopamine-.beta.-hydroxylase activity
- Patent Title (中): 多巴胺-β-羟化酶的酯前体药物，抑制剂，含有它们的组合物以及使用它们抑制多巴胺-β-羟化酶活性的方法
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Application No.: US849333Application Date: 1986-04-08
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Publication No.: US4743613APublication Date: 1988-05-10
- Inventor: James S. Frazee , Carl Kaiser , Lawrence I. Kruse , Stephen T. Ross
- Applicant: James S. Frazee , Carl Kaiser , Lawrence I. Kruse , Stephen T. Ross
- Applicant Address: PA Philadelphia
- Assignee: SmithKline Beckman Corporation
- Current Assignee: SmithKline Beckman Corporation
- Current Assignee Address: PA Philadelphia
- Main IPC: A61K31/415
- IPC: A61K31/415 ; A61P1/04 ; A61P7/10 ; A61P9/04 ; A61P9/08 ; A61P9/12 ; C07D233/84
Abstract:
Compounds having the formula: ##STR1## which are ester prodrugs of potent dopamine-.beta.-hydroxylase inhibitors and thus are useful to inhibit dopamine-.beta.-hydroxylase activity, pharmeceutical compositions including these compounds, and methods of using these compounds to inhibit dopamine-.beta.-hydroxylase activity in mammals.
Public/Granted literature
- US5959761A Incorporating photochromic molecules in light transmissible articles Public/Granted day:1999-09-28
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