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发明授权
US4749691A Peptide, process for preparation thereof and use thereof 失效
肽，其制备方法及其用途

Peptide, process for preparation thereof and use thereof
摘要：
The invention relates to novel peptides of enhanced pharmacological activity of the formula: ##STR1## wherein R.sup.1 is hydroxyalkanoyl,R.sup.2 and R.sup.q are each hydrogen, carboxy, protected carboxy, or a group of the formula: ##STR2## wherein R.sub.a.sup.2 is mono- or di-carboxy (or protected carboxy) lower alkyl or ar(carboxy or protected carboxy) lower alkyl whose aryl moiety may be substituted by hydroxy, R.sup. 2 is hydrogen or lower alkyl; R.sup.p is hydrogen, carboxy, protected carboxy, with proviso that when one of R.sup.2 and R.sup.q is hydrogen, then the other is carboxy or protected carboxy or a group of the formula: ##STR3## wherein R.sub.a.sup.2 and R.sub.b.sup.2 are each as defined above; R.sup.r is hydrogen or amino protective group; m is an integer 1 to 3;or its pharmaceutically acceptable salt.
摘要（中）：

本发明涉及增强的药理活性的新肽，其具有下式：其中R 1是羟基烷酰基，R 2和R q各自是氢，羧基，被保护的羧基或下式的基团：其中Ra 2是单 - 或 二羧基（或被保护的羧基）低级烷基或芳基部分可以被羟基取代的芳（羧基或被保护的羧基）低级烷基，R 2是氢或低级烷基; Rp是氢，羧基，受保护的羧基，条件是当R 2和R q中的一个是氢时，另一个是羧基或保护的羧基或下式的基团：其中Ra2和Rb2各自如上所定义; Rr为氢或氨基保护基; m为整数1〜3; 或其药学上可接受的盐。

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