发明授权
- 专利标题: Indazole derivatives
- 专利标题(中): 吲唑衍生物
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申请号: US739061申请日: 1985-05-29
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公开(公告)号: US4751302A公开(公告)日: 1988-06-14
- 发明人: Tadayuki Ibuki , Taisuke Sugihara , Hiromu Kawakubo , Takanori Sone
- 申请人: Tadayuki Ibuki , Taisuke Sugihara , Hiromu Kawakubo , Takanori Sone
- 申请人地址: JPX
- 专利权人: Asahi Kasei Kogyo Kabushiki Kaisha
- 当前专利权人: Asahi Kasei Kogyo Kabushiki Kaisha
- 当前专利权人地址: JPX
- 优先权: JPX57-40686 19820317; JPX57-40687 19820317; JPX57-40688 19820317; JPX57-40689 19820317; JPX57-40690 19820317; JPX57-40691 19820317; JPX57-40192 19820317
- 主分类号: C07D231/56
- IPC分类号: C07D231/56 ; C07D295/067 ; C07D295/092 ; C07D401/06 ; C07D403/04 ; A61K31/415 ; C07C87/00
摘要:
A compound of the formula (I): ##STR1## wherein W.sub.1 and W.sub.2 each independently is a hydrogen atom or a ##STR2## wherein Y is a n-C.sub.1-6 alkylene group or a n-C.sub.1-6 alkylene group having a C.sub.1-6 alkyl group substituent; and R.sub.1 and R.sub.2 each independently is a hydrogen atom or a C.sub.1-6 alkyl group, and ##STR3## may form a saturated heterocyclic ring selected from the group consisting of morpholino, pyrrolidino, piperidino, homopiperidino and piperazino groups, and the saturated heterocyclic ring except the morpholino group may have at least one C.sub.1-4 alkyl group, hydroxyl group or halogen atom as a substituent;Z.sub.1 is a hydrogen atom, a chlorine atom, a bromine atom, an iodine atom, a hydroxyl group, an amino group, a C.sub.1-3 alkyl group or a methoxy group;Z.sub.2 is a hydrogen atom or an amino group;when W.sub.1 and W.sub.2 are both hydrogen atoms, Z.sub.1 is a hydroxyl group or an iodine atom and Z.sub.2 is hydrogen atom, or Z.sub.1 and Z.sub.2 are both amino groups;when Z.sub.1 and Z.sub.2 are both hydrogen atoms, the ##STR4## in either W.sub.1 or W.sub.2 is a morpholino group; when Z.sub.1 is a chlorine atom, a hydroxyl group, an iodine atom, a methyl group or a methoxy group, Z.sub.2 is a hydrogen atom;when Z.sub.1 is an amino group, Z.sub.2 is a hydrogen atom or an amino group;when Z.sub.1 is a methyl group, a methoxy group or an amino group, Z.sub.1 is in the 5-position; when Z.sub.1 is an iodine atom, Z.sub.1 is in the 5- or 7-position; and when Z.sub.1 and Z.sub.2 are both amino groups, Z.sub.1 and Z.sub.2 are in the 5- and 7-positions;and the physiologically acceptable acid addition salt thereof.
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