发明授权
- 专利标题: 3,3-disubstituted indolines
- 专利标题(中): 3,3-二取代的中吲哚
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申请号: US944953申请日: 1987-01-05
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公开(公告)号: US4760083A公开(公告)日: 1988-07-26
- 发明人: Melvyn J. Myers , Victor J. Nickolson
- 申请人: Melvyn J. Myers , Victor J. Nickolson
- 申请人地址: DE Wilmington
- 专利权人: E. I. Dupont de Nemours & Company
- 当前专利权人: E. I. Dupont de Nemours & Company
- 当前专利权人地址: DE Wilmington
- 主分类号: C07D401/06
- IPC分类号: C07D401/06 ; A61K31/44 ; A61K31/4427 ; A61K31/495 ; A61K31/50 ; A61K31/505 ; A61K31/53 ; A61P25/00 ; A61P25/02 ; A61P37/00 ; C07D401/14 ; C07D403/06 ; C07D403/14 ; C07D209/34 ; A61K31/40
摘要:
Cognitive deficiencies and/or neurological function deficits and/or mood and/or mental disturbances are treated by the administration of 3,3-disubstituted indolines. The indolines have the formula: ##STR1## wherein: p is 0 or 1;Z is O or S;R is C.sub.1 -C.sub.10 alkyl, C.sub.3 -C.sub.8 cycloalkyl, 2-pyridyl, 3-pyridyl, 4-pyridyl or ##STR2## V, W, X, and Y independently are H, halo, C.sub.1 -C.sub.3 alkyl, OR.sup.1, NO.sub.2, CF.sub.3, CN or NR.sup.2 R.sup.2 ;R.sup.1 and R.sup.2 independently are H or C.sub.1 -C.sub.3 alkyl;-- .circle.H and -- .circle.H' independently are 6-membered heterocyclic aromatic rings containing at least one nitrogen atom as a part of the ring optionally substituted with one substituent selected from the group C.sub.1 -C.sub.3 alkyl, halo, OR.sup.1 or NR.sup.1 R.sup.2 ; oran N-oxide or pharmaceutically suitable acid addition salt thereof.
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