发明授权
US4772621A Antihypertensive diphenylpropyl aminopropyl ester of
1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acid
失效
1,4-二氢-2,6-二甲基 - 吡啶-3,5-二羧酸的抗高血压二苯基丙基氨基丙酯
- 专利标题: Antihypertensive diphenylpropyl aminopropyl ester of 1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acid
- 专利标题(中): 1,4-二氢-2,6-二甲基 - 吡啶-3,5-二羧酸的抗高血压二苯基丙基氨基丙酯
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申请号: US086739申请日: 1987-08-19
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公开(公告)号: US4772621A公开(公告)日: 1988-09-20
- 发明人: Dante Nardi , Amedeo Leonardi , Gabriele Graziani , Giorgio Bianchi
- 申请人: Dante Nardi , Amedeo Leonardi , Gabriele Graziani , Giorgio Bianchi
- 申请人地址: CHX Chiasso
- 专利权人: Recordati S.A., Chemical and Pharmaceutical Company
- 当前专利权人: Recordati S.A., Chemical and Pharmaceutical Company
- 当前专利权人地址: CHX Chiasso
- 优先权: GBX8403866 19840214
- 主分类号: A61K31/41
- IPC分类号: A61K31/41 ; A61K31/435 ; A61K31/44 ; A61K31/455 ; A61P9/08 ; A61P9/10 ; A61P9/12 ; C07C67/00 ; C07C201/00 ; C07C205/56 ; C07D211/90 ; C07D413/04 ; C07D413/14
摘要:
Novel antihypertensive and coronary dilating asymmetric diesters of 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylic acid (or the stereoisomers or pharmaceutically acceptable acid addition salts thereof) have the general formula (I): ##STR1## wherein Ph is phenyl, Ar is 2-nitrophenyl, 3-nitrophenyl, 2,3-dichlorophenyl or benzofurazan-4-yl, A is a straight or branched chain alkylene radical having from 2 to 6 carbon atoms, R is a straight or branched chain alkyl radical having from 1 to 6 carbon atoms, optionally mono-substituted by an alkoxy substituent having from 1 to 6 carbon atoms, R.sub.1 is hydrogen, hydroxy or an alkyl radical having from 1 to 4 carbon atoms, and R.sub.2 is hydrogen or methyl. The subject diesters are facilely prepared from the aldehydes ArCHO and esters of acetoacetic and 3-aminocrotonic acids.
公开/授权文献
- USD420284S Tubular food container 公开/授权日:2000-02-08