发明授权
US4782052A Octahydroindolo[2,3-a]quinolizin-1-yl-alkanecarboxylic acid amines and
their therapeutically useful acid addition salts, pharmaceutical
compositions containing them and process for preparing same
失效
八氢吲哚并[2,3-a]喹嗪酮-1-基 - 链烷羧酸胺及其治疗上有用的酸加成盐,含有它们的药物组合物及其制备方法
- 专利标题: Octahydroindolo[2,3-a]quinolizin-1-yl-alkanecarboxylic acid amines and their therapeutically useful acid addition salts, pharmaceutical compositions containing them and process for preparing same
- 专利标题(中): 八氢吲哚并[2,3-a]喹嗪酮-1-基 - 链烷羧酸胺及其治疗上有用的酸加成盐,含有它们的药物组合物及其制备方法
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申请号: US783911申请日: 1985-10-03
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公开(公告)号: US4782052A公开(公告)日: 1988-11-01
- 发明人: Ferenc Soti , Csaba Szantay , Maria Incze , Zsuzsanna Balogh nee Kardos , Elemer Ezer , Judit Matuz , Laszlo Szporny , Gyorgy Hajos , Csaba Kuthi
- 申请人: Ferenc Soti , Csaba Szantay , Maria Incze , Zsuzsanna Balogh nee Kardos , Elemer Ezer , Judit Matuz , Laszlo Szporny , Gyorgy Hajos , Csaba Kuthi
- 申请人地址: HUX Budapest
- 专利权人: Richter Gedeon Vegyeszeti Gyar Rt.
- 当前专利权人: Richter Gedeon Vegyeszeti Gyar Rt.
- 当前专利权人地址: HUX Budapest
- 优先权: HUX3776/84 19841005
- 主分类号: C07D487/14
- IPC分类号: C07D487/14 ; A61K31/404 ; A61K31/435 ; A61K31/4375 ; A61K31/454 ; A61K31/475 ; A61P1/04 ; A61P9/06 ; A61P9/08 ; A61P21/02 ; C07D209/04 ; C07D221/00 ; C07D471/14 ; C07D471/22 ; A61K31/55 ; A61K31/535 ; C07D471/04
摘要:
The invention relates to new 1,2,3,4,6,7,12,12b-octahydroindolo[2,3,-a]quinolizin-1-yl-alkanecarboxylic acid amides of the formula (I), ##STR1## wherein R.sub.1 and R.sub.2 stand independently for a hydrogen or halogen atom, or a hydroxyl, nitro or C.sub.1-4 alkoxy group;R.sub.3 and R.sub.4 stand independently for a hydrogen atom or a C.sub.1-4 alkyl group;R.sub.5 and R.sub.6 stand independently for a hydrogen atom, C.sub.1-8 alkyl group, C.sub.3-8 alkenyl or cycloalkyl group, aryl or aralkyl group, heteroaryl or heteroaralkyl group containing oxygen, nitrogen or sulphur atom, all these groups being optionally substituted; orR.sub.5 and R.sub.6 together form an optionally substituted C.sub.2-8 .alpha.,.omega.-alkylene group, wherein one carbon atom may optionally be replaced by an oxygen or nitrogen atom; andG means a C.sub.1-4 straight chained alkylene group, as well as to their therapeutically suitable acid addition salts and pharmaceutical compositions containing these compounds. The compounds of the formula (I) have valuable therapeutic properties, namely vasodilatory, spasmolytic, antiarrhythmic and gastrocytoprotective effects. The gastrocytoprotective effect is particularly important.
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