发明授权
- 专利标题： Coronary-active fluorine-containing 1,4-dihydropyridines
- 专利标题（中）： 冠状活性含氟1,4-二氢吡啶类
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申请号： US937764申请日： 1986-12-04
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公开(公告)号： US4798840A公开(公告)日： 1989-01-17
- 发明人: Egbert Wehinger , Horst Meyer , Andreas Knorr , Stanislav Kazda
- 申请人： Egbert Wehinger , Horst Meyer , Andreas Knorr , Stanislav Kazda
- 申请人地址： DEX Leverkusen
- 专利权人： Bayer Aktiengesellschaft
- 当前专利权人： Bayer Aktiengesellschaft
- 当前专利权人地址： DEX Leverkusen
- 优先权： DEX3544211 19851213
- 主分类号： A61K31/4427
- IPC分类号： A61K31/4427 ; A61K31/455 ; A61P9/08 ; A61P9/12 ; C07D211/90 ; C07D401/04 ; C07D401/06 ; C07D401/12 ; C07D413/04
摘要：
Hypotensive long-acting 1,4-dihydropyridines of the formula ##STR1## in which R.sup.1 is phenyl or heterocyclic,R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the usual definitions in such compounds,R.sup.6 represents hydrogen or a lower alkyl radical or the trifluoromethyl group,R.sup.7 and R.sup.8 each denote a hydrogen atom or a fluorine atom,n.gtoreq.1 andm.gtoreq.0, and the sum of n and m must be a least 4, andX represents a single bond, an oxygen atom or the group --N(alkyl)--O.sub.2 S--,or pharmacologically acceptable acid addition salts thereof.
公开/授权文献
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