发明授权
US4812451A 1-(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl)-.alpha.,.alpha
.
失效
1-(氨基烷基和氨基烷基氨基)羰基和硫代羰基)-α,α二芳基吡咯烷,哌啶和高哌啶乙酰胺和乙腈
- 专利标题: 1-(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl)-.alpha.,.alpha .
- 专利标题(中): 1-(氨基烷基和氨基烷基氨基)羰基和硫代羰基)-α,α二芳基吡咯烷,哌啶和高哌啶乙酰胺和乙腈
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申请号: US845148申请日: 1986-03-27
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公开(公告)号: US4812451A公开(公告)日: 1989-03-14
- 发明人: James R. Shanklin, Jr. , James M. Wilkinson, II
- 申请人: James R. Shanklin, Jr. , James M. Wilkinson, II
- 申请人地址: VA Richmond
- 专利权人: A. H. Robins Company, Incorporated
- 当前专利权人: A. H. Robins Company, Incorporated
- 当前专利权人地址: VA Richmond
- 主分类号: C07D207/08
- IPC分类号: C07D207/08 ; C07D211/34 ; C07D211/42 ; C07D223/04 ; A61K31/445
摘要:
Novel 1-[(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl-.alpha.,.alpha.-diaryl-pyrrolidine, piperidine and homopiperidineacetamides and acetonitriles having the formula: ##STR1## wherein; n is zero, one or two;X is oxygen or sulfur;Z is ##STR2## 10 or --(CH.sub.2); p is 0 to 5 inclusive with the proviso that when Z is ##STR3## p is at least one; Y is aminocarbonyl or cyano;Ar.sup.1 and Ar.sup.2 are 2, 3 or 4-pyrido, phenyl or substituted phenyl;R is hydrogen or loweralkyl;R.sup.1, R.sup.2 and R.sup.3 are hydrogen, cycloalkyl, loweralkyl, phenyl, substituted phenyl, phenylloweralkyl, and R.sup.2 and R.sup.3 taken with the adjacent nitrogen may form a heterocyclic residue, and diastereoisomers when possible and pharmaceutical salts; and the method and pharmaceutical compositions for treating cardiac arrhythmias therewith are disclosed.
公开/授权文献
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