发明授权
US4829076A Novel dihydropyridines having calcium antagonistic and antihypertensive
activity
失效
具有钙拮抗作用和抗高血压活性的新型二氢吡啶类
- 专利标题： Novel dihydropyridines having calcium antagonistic and antihypertensive activity
- 专利标题（中）： 具有钙拮抗作用和抗高血压活性的新型二氢吡啶类
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申请号： US97111申请日： 1987-09-16
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公开(公告)号： US4829076A公开(公告)日： 1989-05-09
- 发明人: Geza Szilagyi , Eva Bozo , Laszlo Czollner , Laszlo Jaszlits , Gyorgy Rabloczky , Jozsef Borsi , Istvan Elekes , Gyongyi Nagy nee Csokas , Andras Varro , ZSuzanne Lang nee Rihmer , Gyorgy Cseh , Gyula Horvath , Ilona Bodi
- 申请人： Geza Szilagyi , Eva Bozo , Laszlo Czollner , Laszlo Jaszlits , Gyorgy Rabloczky , Jozsef Borsi , Istvan Elekes , Gyongyi Nagy nee Csokas , Andras Varro , ZSuzanne Lang nee Rihmer , Gyorgy Cseh , Gyula Horvath , Ilona Bodi
- 申请人地址： HUX Tiszavasvari
- 专利权人： Alkaloida Vegyeszeti Gyar
- 当前专利权人： Alkaloida Vegyeszeti Gyar
- 当前专利权人地址： HUX Tiszavasvari
- 优先权： HUX3948/86 19860916
- 主分类号： A61K31/445
- IPC分类号： A61K31/445 ; A61K31/451 ; A61K31/455 ; A61P3/00 ; A61P9/10 ; A61P9/12 ; C07D211/90 ; C07D401/12 ; C07D405/12
摘要：
The invention relates to new substituted dihydropyridine derivatives of the general formula (I), ##STR1## wherein R.sup.1 and R.sup.6 are as defined herein after, the racemic and optically active variants as well as mixtures thereof, furthermore the acid addition salts of these compounds, pharmaceutical compositions containing the same and a process for the preparation thereof.The compounds of the general formula (I) can be advantageously applied for the treatment of pathologically severe hypertensions, their toxicity is low and they possess an advantageous therapeutic index.
公开/授权文献
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