A brake control system for effectively properly performing a braking hydraulic pressure distribution between a front wheel and a rear wheel or a left wheel and a right wheel of a motor vehicle including a master cylinder for generating a hydraulic pressure in response to depression of a brake pedal thereof and applying the hydraulic pressure through first and second braking passages to first and second wheel braking cylinders. This brake control system has first and second pressure control devices respectively coupled to a braking pressure source for allowing the output hydraulic pressures to be regulated independently of each other under control of a control unit. The output of the first pressure control device is coupled through the first braking passage to the first wheel braking cylinder and the output of the second pressure control device is coupled through the second braking passage to the second wheel braking cylinder. The control unit determines first and second target braking pressures to the first and second wheel braking cylinders on the basis of the hydraulic pressure in the master cylinder. The determined first and second target braking pressures are respectively corrected on the basis of the vehicle acceleration and wheel slip ratios.