发明授权
US4837349A Tertiary-butyldimethylsilyl carbamate derivative and process for
producing the same
失效
叔丁基二甲基甲硅烷基氨基甲酸酯衍生物及其制备方法
- 专利标题: Tertiary-butyldimethylsilyl carbamate derivative and process for producing the same
- 专利标题(中): 叔丁基二甲基甲硅烷基氨基甲酸酯衍生物及其制备方法
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申请号: US909397申请日: 1986-09-19
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公开(公告)号: US4837349A公开(公告)日: 1989-06-06
- 发明人: Yasufumi Ohfune , Masahiro Sakaitani
- 申请人: Yasufumi Ohfune , Masahiro Sakaitani
- 申请人地址: JPX Osaka
- 专利权人: Suntory Limited
- 当前专利权人: Suntory Limited
- 当前专利权人地址: JPX Osaka
- 优先权: JPX60-207204 19850919; JPX61-16343 19860711
- 主分类号: C07F7/18
- IPC分类号: C07F7/18
摘要:
A t-butyldimethylsilyl carbamate derivative and a process for producing the same are disclosed. Tertiary-butyldimethylsilyl carbamate derivatives having the following general formula (1) are intermediates for the production of a variety of carbamate esters that can be extensively used as drugs acting on the central nervous system or circulatory organs, as agrichemicals (e.g. insecticides and herbicides), or as antimicrobial agents; a process capable of economical and efficient production of such intermediates is also disclosed: ##STR1## where R.sup.1 is an alkyl group having 1-3 carbon atoms or a hydrogen atom; R.sup.2 is ##STR2## (where R.sup.3 is a hydrogen atom, an alkyl, alkenyl or aralkyl group having 1-10 carbon atoms, each of which groups may be substituted by a hydroxyl group, a t-butyldimethylsilyloxy group, a methylthio group, a lower alkoxycarbonyl group, a lower alkoxy group, an indolyl group or an imidazolyl group; R.sup.4 is a lower alkoxycarbonyl group, an N-alkylamido group having 2-6 carbon atoms, an O-tetrahydropyranylthr eonine methyl ester amido residue, an O-t-butyldimethylsilylthreonine methyl ester amido residue, a threonine methyl ester amido residue or --(CH.sub.2).sub.n --COOR.sup.5 (where n is an integer of 1-3 and R.sup.5 is a lower alkyl group), provided that R.sup.3 combines with R.sup.4 to form a cyclopentyl group, a cyclohexyl group, a tetrahydrofuranyl group or a dioxanyl group, these rings being optionally substituted by a lower alkyl group, a lower alkenyl group, a lower alkoxycarbonyl group or a lower alkoxycarbonylmethyl group); and R.sup.1 and R.sup.2, when taken together, form a 4- or 5-membered carbon ring, which may be substituted by a lower alkoxycarbonyl group or a t-butyldimethylsilyloxycarbonyl group.
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