发明授权
US4839364A 9-Amino-3,4-dihydroacridines and related compounds useful for enhancing
memory
失效
9-氨基-3,4-二氢吖啶和有助于增强记忆的相关化合物
- 专利标题： 9-Amino-3,4-dihydroacridines and related compounds useful for enhancing memory
- 专利标题（中）： 9-氨基-3,4-二氢吖啶和有助于增强记忆的相关化合物
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申请号： US7885申请日： 1987-01-28
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公开(公告)号： US4839364A公开(公告)日： 1989-06-13
- 发明人: Gregory M. Shutske , Frank A. Pierrat
- 申请人： Gregory M. Shutske , Frank A. Pierrat
- 申请人地址： NJ Somerville
- 专利权人： Hoechst-Roussel Pharmaceuticals, Inc.
- 当前专利权人： Hoechst-Roussel Pharmaceuticals, Inc.
- 当前专利权人地址： NJ Somerville
- 主分类号： C07C255/42
- IPC分类号： C07C255/42 ; A61K31/435 ; A61K31/47 ; C07C20060101 ; C07C67/00 ; C07C253/00 ; C07C255/58 ; C07C255/59 ; C07C255/60 ; C07D219/08 ; C07D219/10 ; C07D219/12 ; C07D221/16 ; C07D409/12
摘要：
There are disclosed compounds having the formula ##STR1## wherein n is 1, 2 or 3; X is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, NHCOR.sub.2 where R.sub.2 is loweralkyl, or NR.sub.3 R.sub.4 where R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl; R is hydrogen or loweralkyl; R.sub.1 is hydrogen, loweralkyl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralkyl, furylloweralkyl, thienylloweralkyl, oxygen-bridged arylloweralkyl, oxygen-bridged diarylloweralkyl, oxygen-bridged furylloweralkyl or oxygen-bridged thienylloweralkyl; Y is C.dbd.O or CR.sub.5 OH where R.sub.5 is hydrogen or loweralkyl; Z is CH.sub.2 or C.dbd.CR.sub.6 R.sub.7 where R.sub.6 and R.sub.7 are independently hydrogen or loweralkyl; or Y and Z taken together is CR.sub.5 .dbd.Ch where CR.sub.5 and CH correspond to Y and Z respectively; an optical antipode thereof, or a pharmaceutically acceptable acid addition salt thereof, which are useful for enhancing memory, methods for synthesizing them, and pharmaceutical compositions comprising an effective memory enhancing amount of such a compound.
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