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发明授权
US4843091A Indolylpropionic acids, compositions of, and use thereof to inhibit thrombocyte aggregation 失效
吲哚丙酸，其组合物及其用途，用于抑制血小板聚集

Indolylpropionic acids, compositions of, and use thereof to inhibit thrombocyte aggregation
摘要：
An N-sulphonamidoethyl-indole of the formula ##STR1## in which R.sup.1 represents hydrogen, alkyl, alkoxy, alkylthio, halogen, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, difluoromethoxy, aryl, arylthio, aralkyl, aralkoxy, aralkylthio, acyl or a group of the formula ##STR2## in which R.sup.5 and R.sup.6 are identical or different and denote hydrogen, alkyl, aryl, aralkyl or acyl, andR.sup.3 represents hydrogen, alkyl, aryl, pyridyl, thienyl or furyl, andR.sup.4 represents hydrogen, alkyl, alkoxy, alkylthio, halogen, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, aryl, aryloxy, arylthio, aralkyl, aralkoxy, aralkylthio, acl or a group of the formula ##STR3## in which R.sup.7 and R.sup.8 are identical or different and denote hydrogen, alkyl, aryl, aralkyl or acyl,R.sup.5 represents hydrogen, ##STR4## or a pharmacologically acceptable salt of ##STR5## and R.sup.2 represents hydrogen, alkyl or aryl.The compounds were R.sup.5 is ##STR6## or a salt thereof inhibit the aggregation of thrombocytes.
摘要（中）：

其中R 1表示氢，烷基，烷氧基，烷硫基，卤素，三氟甲基，三氟甲氧基，三氟甲硫基，二氟甲氧基，芳基，芳硫基，芳烷基，芳烷氧基，芳烷硫基，酰基或一组基团的N-磺酰氨基乙基 - 吲哚 式中，R 5和R 6相同或不同，表示氢，烷基，芳基，芳烷基或酰基，R 3表示氢，烷基，芳基，吡啶基，噻吩基或呋喃基，R 4表示氢，烷基，烷氧基，烷硫基 卤素，三氟甲基，三氟甲氧基，三氟甲硫基，芳基，芳氧基，芳硫基，芳烷基，芳烷氧基，芳烷硫基，acl或其中R 7和R 8相同或不同并表示氢，烷基，芳基，芳烷基或 酰基，R 5表示氢，或者是IMA IMA的药理学上可接受的盐，R 2表示氢，烷基或芳基。 化合物是R5是抑制凝血细胞聚集的盐或其盐。

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