发明授权
US4847412A Process for racemizing an optically active N-benzylidene amino-acid amide
失效
使光学活性的N-亚苄基氨基酸酰胺外消旋化的方法
- 专利标题: Process for racemizing an optically active N-benzylidene amino-acid amide
- 专利标题(中): 使光学活性的N-亚苄基氨基酸酰胺外消旋化的方法
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申请号: US850157申请日: 1986-04-10
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公开(公告)号: US4847412A公开(公告)日: 1989-07-11
- 发明人: Wilhelmus H. J. Boesten , Hans E. Schoemaker , Bernardus H. N. Dassen
- 申请人: Wilhelmus H. J. Boesten , Hans E. Schoemaker , Bernardus H. N. Dassen
- 申请人地址: NLX
- 专利权人: Stamicarbon B.V.
- 当前专利权人: Stamicarbon B.V.
- 当前专利权人地址: NLX
- 优先权: NLX8501093 19850412
- 主分类号: C07B55/00
- IPC分类号: C07B55/00 ; C07B31/00 ; C07C67/00 ; C07C231/00 ; C07C231/12 ; C07C231/16 ; C07C237/06 ; C07C241/00 ; C07C251/02 ; C12P13/04 ; C12P13/08 ; C12P41/00
摘要:
The invention relates to a process for racemizing an optically active N-benzylidene amino-acid amide, characterized in that a solution of the N-benzylidene amino-acid amide is mixed in a water-miscible organic solvent with at least 0.05 mole strong base per liter solution.The invention further relates to a process for preparing an L-amino acid by enzymatic separation of the corresponding DL-amino-acid amide with an enzyme preparation from Pseudomonas putida, in which process also unconverted D-amino-acid amide is left behind in solution, characterized in that benzaldehyde is added to the solution, during which addition a precipitate of D-N-benzylidene amino-acid amide is being formed, this precipitate is subsequently, after being separated off, dissolved in an acetone-water mixture, 0.08-0.15 mole KOH/liter solution is subsequently added, the resulting solution is stirred for 1-20 hours at 20.degree.-60.degree. C., sulphuric acid is then added until the pH of the solution is 5 and the resulting sulphuric acid salt of the DL-amino-acid amide is finally, after isolation at pH 8-10, converted into the DL-amino-acid amide and this DL-amino-acid amide is used again.
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