发明授权
- 专利标题: Pyrimidine derivatives
- 专利标题(中): 嘧啶衍生物
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申请号: US080021申请日: 1987-07-31
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公开(公告)号: US4851519A公开(公告)日: 1989-07-25
- 发明人: Robert W. Lambert , Joseph A. Martin , Gareth J. Thomas
- 申请人: Robert W. Lambert , Joseph A. Martin , Gareth J. Thomas
- 申请人地址: NJ Nutley
- 专利权人: Hoffmann-La Roche Inc.
- 当前专利权人: Hoffmann-La Roche Inc.
- 当前专利权人地址: NJ Nutley
- 优先权: GBX8620070 19860818; GBX8711336 19870514
- 主分类号: C07D405/04
- IPC分类号: C07D405/04 ; A61K31/505 ; A61P31/12 ; C07D405/14 ; C07D409/14 ; C07H19/06
摘要:
Compounds of the formula ##STR1## wherein R.sup.1 is halogen, C.sub.1-4 -alkyl, halo-(C.sub.1-4 -alkyl) or C.sub.2-4 -alkanoyl,R.sup.2 is hydrogen, hydroxy, C.sub.1-4 alkoxy, C.sub.1-4 -alkylthio or phenyl-(C.sub.1-4 -alkoxy) or , when X is O, also acyloxy,R.sup.3 is hydrogen or C.sub.1-4 -alkyl,R.sup.4 is a carbocyclic group or a heterocyclic group,R.sup.5 is hydrogen or fluorine,m stands for zero, 1 or 2,X is O or NH and Y is a direct bond, --CH.dbd.CH--, --C.tbd.C-- or a group of the formula of--(Z).sub.n --A-- (a)in which A is a C.sub.1-8 alkylene group which is optionally substituted by one or two phenyl groups,Z is O, S, SO or SO.sub.2 and n stands for zero or 1, with the proviso that R.sup.1 is different from iodine, when R.sup.2 is hydroxy or benzoyloxy, R.sup.3 is hydrogen,R.sup.4 is unsubstituted phenyl, R.sup.5 is hydrogen, m stands for zero, X is O, and Y is a direct bond, and tautomers thereof, which possess antiviral activity and can therefore be used in the form of medicaments for the control and prevention of viral infections are described. The compounds of formula I can be prepared according to known methods.
公开/授权文献
- USD404654S Watchcase 公开/授权日:1999-01-26