Invention Grant
US4872561A Carboxy, carboalkoxy and carbamile substituted isonitrile radionuclide
complexes
失效
羧基，烷氧羰基和氨基甲酰取代的异腈核苷配合物
- Patent Title: Carboxy, carboalkoxy and carbamile substituted isonitrile radionuclide complexes
- Patent Title (中): 羧基，烷氧羰基和氨基甲酰取代的异腈核苷配合物
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Application No.: US139289Application Date: 1987-12-29
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Publication No.: US4872561APublication Date: 1989-10-10
- Inventor: Alun G. Jones , Alan Davison , James Kronauge , Michael J. Abrams
- Applicant: Alun G. Jones , Alan Davison , James Kronauge , Michael J. Abrams
- Applicant Address: MA Cambridge MA Cambridge
- Assignee: Massachusetts Institute of Technology,President and Fellows of Harvard College
- Current Assignee: Massachusetts Institute of Technology,President and Fellows of Harvard College
- Current Assignee Address: MA Cambridge MA Cambridge
- Main IPC: A61K51/00
- IPC: A61K51/00 ; A61K51/04 ; C07F13/00
Abstract:
A coordination complex comprising a radionuclide selected from the class consisting of radioactive isotopes of Tc, Ru, Co, Pt and Re and an isonitrile ligand of the formula:(CNX)R,where X is a lower alkyl group having 1 to 4 carbon atoms, wherein R is selected from the group consisting of COOR.sup.1 and CONR.sup.2 R.sup.3 where R.sup.1 can be H, a pharmaceutically acceptable cation, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms. R.sup.2, and R.sup.3 can be H, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, and R.sup.2 and R.sup.3 can be the same of different is disclosed. Kits that can be used to form these complexes are also disclosed.
Public/Granted literature
- US6016989A Paper web autosplicer Public/Granted day:2000-01-25
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