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公开(公告)号：US11287047B1
公开(公告)日：2022-03-29
申请号：US16862743
申请日：2020-04-30
Applicant: Clay Owens , Alan Davison , Chris Clouse , Jerry George McGarrah
Inventor： Clay Owens , Alan Davison , Chris Clouse , Jerry George McGarrah
Abstract: A split body, rotary C gate, removeable stem vacuum valve using an input assembly with handle extensions that allow for hand movement of the incoming pipe to access an inner aperture body with a curved sealing face that directly seals to a C shaped gasketless gate that can be rotated into and out of the inner body aperture for easy cleaning. The gasketless gate is held in position using gate axles with an outer axle stem connected to a polygon lower body that mates into a matching polygon aperture on the gasketless gate. The middle valve assembly's gasketless housing body defines upper and lower axle washer pockets for locating the axles for proper operation and simple axle pins for securing the axles in position.
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公开(公告)号：US4826961A
公开(公告)日：1989-05-02
申请号：US6562
申请日：1987-01-22
Applicant: Alun G. Jones , Alan Davison , Michael J. Abrams
Inventor： Alun G. Jones , Alan Davison , Michael J. Abrams
CPC classification number: C07F13/00 , A61K51/0476 , C07F3/06 , A61K2123/00
Abstract: A method for preparing radiopharmaceutical complexes that are substantially free of the reaction materials used to produce the radiopharmaceutical complex is disclosed. The method involves admixing in a suitable first solvent in a container a target seeking ligand or salt or metal adduct thereof, a radionuclide label, and a reducing agent for said radionuclide, thereby forming said radiopharmaceutical complex; coating the interior walls of the container with said pharmaceutical complex; discarding the solvent containing by-products and unreacted starting reaction materials; and removing the radiopharmaceutical complex from said walls by dissolving it in a second solvent, thereby obtaining said radiopharmaceutical complex substantially free of by-products and unreacted starting materials.
Abstract translation: 公开了一种制备基本上不含用于制备放射性药物复合物的反应材料的放射性药物复合物的方法。 该方法包括在合适的第一溶剂中在适当的第一溶剂中混合目的物，寻找配体或其盐或金属加成物，放射性核素标记和用于所述放射性核素的还原剂，从而形成所述放射性药物复合物; 用所述药物复合物涂覆容器的内壁; 丢弃含有副产物和未反应的起始反应物质的溶剂; 并通过将其溶解在第二溶剂中从所述壁中除去放射性药物复合物，从而获得基本上不含副产物和未反应起始物质的所述放射性药物复合物。
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3.发明授权Carboxy, carboalkoxy and carbamile substituted isonitrile radionuclide complexes 失效羧基，烷氧羰基和氨基甲酰取代的异腈核苷配合物
公开(公告)号：US4735793A
公开(公告)日：1988-04-05
申请号：US771284
申请日：1985-08-30
Applicant: Alun G. Jones , Alan Davison , James Kronauge , Michael J. Abrams
Inventor： Alun G. Jones , Alan Davison , James Kronauge , Michael J. Abrams
IPC: C07B59/00 , A61K31/28 , A61K31/282 , A61K33/24 , A61K51/00 , A61K51/04 , C07B31/00 , C07C67/00 , C07C325/00 , C07C395/00 , C07F13/00 , C07F15/00 , C07F15/06 , A61K43/00 , A61K49/02 , C07C119/02
CPC classification number: C07F13/005 , A61K51/0476 , C07C251/00 , A61K2123/00
Abstract: A coordination complex comprising a radionuclide selected from the class consisting of radioactive isotopes of Tc, Ru, Co, Pt and Re and an isonitrile ligand of the formula:(CNX)R,where X is a lower alkyl group having 1 to 4 carbon atoms, wherein R is selected from the group consisting of COOR.sup.1 and CONR.sup.2 R.sup.3 where R.sup.1 can be H, a pharmaceutically acceptable cation, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, R.sup.2, and R.sup.3 can be H, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, and R.sup.2 and R.sup.3 can be the same or different is disclosed. Kits that can be used to form these complexes are also disclosed.
Abstract translation: 包含选自Tc，Ru，Co，Pt和Re的放射性同位素的放射性核素的配位络合物和式（CNX）R的异腈配体，其中X是具有1至4个碳原子的低级烷基 其中R选自COOR1和CONR2R3，其中R1可以是H，药学上可接受的阳离子或具有1至4个碳原子的取代或未取代的烷基，R 2和R 3可以是H，或者取代或 未取代的具有1至4个碳原子的烷基，R2和R3可以相同或不同。 还可以公开可用于形成这些络合物的试剂盒。
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4.发明授权Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents 失效用于制备锝放射性诊断肾脏剂的双酰胺双硫酚化合物
公开(公告)号：US4673562A
公开(公告)日：1987-06-16
申请号：US524888
申请日：1983-08-19
Applicant: Alan Davison , David Brenner , John Lister-James , Alun G. Jones
Inventor： Alan Davison , David Brenner , John Lister-James , Alun G. Jones
IPC: C07B59/00 , A61K51/00 , A61K51/04 , C07B31/00 , C07C67/00 , C07C313/00 , C07C323/25 , C07C323/41 , C07C323/60 , C07F13/00 , C07K1/13 , C07K5/06 , C07K5/083 , A61K43/00 , A61N5/12
CPC classification number: C07K5/0806 , A61K51/0478 , C07C321/00 , C07C323/25 , C07F13/005 , C07K5/0606 , A61K2123/00
Abstract: A radiodiagnostic bisamido-bisthio ligand useful for producing Tc-labelled radiodiagnostic renal agents is described. The ligand forms a complex with the radionuclide .sup.99m Tc suitable for administration as a radiopharmaceutical to obtain images of the kidney for diagnosis of kidney disfunction.
Abstract translation: 描述了可用于产生Tc-标记的放射诊断性肾脏剂的放射性诊断性双酰胺 - 比斯他配体。 该配体与放射性核素99mTc形成复合物，适合作为放射性药物施用，以获得用于诊断肾功能障碍的肾脏图像。
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公开(公告)号：US11953111B1
公开(公告)日：2024-04-09
申请号：US17676993
申请日：2022-02-22
Applicant: Clay Owens , Alan Davison , Chris Clouse , Jerry George McGarrah
Inventor： Clay Owens , Alan Davison , Chris Clouse , Jerry George McGarrah
CPC classification number: F16K27/067 , F16K5/0642 , F16K5/201 , F16K51/02
Abstract: A split body, rotary C gate, removeable stem vacuum valve using an input assembly with handle extensions that allow for hand movement of the incoming pipe to access an inner aperture body with a curved sealing face that directly seals to a C shaped gasketless gate that can be rotated into and out of the inner body aperture for easy cleaning. The gasketless gate is held in position using gate axles with an outer axle stem connected to a polygon lower body that mates into a matching polygon aperture on the gasketless gate. The middle valve assembly's gasketless housing body defines upper and lower axle washer pockets for locating the axles for proper operation and simple axle pins for securing the axles in position.
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Patent Agency Ranking
6.发明授权Small technetium-99m and rhenium labeled agents and methods for imaging tumors 失效小锝-99m和铼标记的药剂和肿瘤成像方法公开(公告)号：US07321027B2
公开(公告)日：2008-01-22
申请号：US10279214
申请日：2002-10-23
Applicant: Ashfaq Mahmood , Matthias Friebe , Cristina Bolzati , Alun G. Jones , Alan Davison
Inventor： Ashfaq Mahmood , Matthias Friebe , Cristina Bolzati , Alun G. Jones , Alan Davison
IPC: C07F13/00
CPC classification number: C07D295/13 , A61K51/0478 , C07C323/41 , C07F13/005 , C07K5/06026
Abstract: The present invention relates to compounds and related technetium and rhenium complexes thereof which are suitable for imaging or therapeutic treatment of tumors, e.g., carcinomas, melanomas and other tumors. In another embodiment, the invention relates to methods of imaging tumors using radiolabeled metal complexes. Preferred radiolabeled complexes for imaging tumors include technetium and rhenium complexes. The high tumor uptake and significant tumor/nontumor ratios of the technetium complexes of the invention indicate that such small technetium-99m-based molecular probes can be developed as in-vivo diagnostic agents for melanoma and its metastases. In yet another embodiment, the invention relates to methods of treatment of tumors using a radiolabeled metal complex as a radiopharmaceutical agent to treat the tumor.
Abstract translation: 本发明涉及适用于肿瘤例如癌，黑素瘤和其他肿瘤的成像或治疗性治疗的化合物及其相关的锝和铼络合物。 在另一个实施方案中，本发明涉及使用放射性标记的金属络合物成像肿瘤的方法。 用于成像肿瘤的优选放射性标记复合物包括锝和铼络合物。 本发明的锝络合物的高肿瘤摄取和显着的肿瘤/非肿瘤比率表明，这种基于锝-99m的小分子探针可以作为黑色素瘤及其转移的体内诊断剂开发。 在另一个实施方案中，本发明涉及使用放射性标记的金属络合物作为放射性药物治疗肿瘤的方法治疗肿瘤。
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公开(公告)号：US06171576B2
公开(公告)日：2001-01-09
申请号：US08552584
申请日：1995-11-03
Applicant: Peter C. Meltzer , Bertha K. Madras , Alan Davison , Paul Blundell , Ashfaq Mahmood , Alun G. Jones
Inventor： Peter C. Meltzer , Bertha K. Madras , Alan Davison , Paul Blundell , Ashfaq Mahmood , Alun G. Jones
IPC: A61K5100
CPC classification number: A61K51/0448 , A61K2123/00 , C07C69/753 , C07C2602/44 , C07D451/02
Abstract: Radiopharmaceutical compounds are disclosed. A tropane compound is linked through the N atom at the 8-position to a chelating ligand capable of complexing technetium or rhenium to produce a neutral labeled complex that selectively binds to the dopamine transporter. These compounds can be prepared as separate diastereoisomers as well as a mixture of diastereoisomers. Also disclosed are radiopharmaceutical kits for preparing the labeled radiopharmaceutical compounds.
Abstract translation: 公开了放射性药物化合物。 托烷化合物通过8位的N原子连接到能够络合锝或铼的螯合配体以产生选择性结合多巴胺转运蛋白的中性标记复合物。 这些化合物可以制备成单独的非对映异构体以及非对映异构体的混合物。 还公开了用于制备标记的放射性药物化合物的放射性药物试剂盒。
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8.发明授权Modular non-cryogenic cooled auger conveyor arrangement for chilling food products, slurries and the like 失效用于冷冻食品，浆料等的模块化非低温冷却螺旋输送机装置
公开(公告)号：US5692382A
公开(公告)日：1997-12-02
申请号：US652406
申请日：1996-05-23
Applicant: Alan Davison
Inventor： Alan Davison
CPC classification number: F25D13/065 , A23L3/361
Abstract: In order to chill foodstuffs and the like type of material a modular chilling unit is provided with a jacketed trough through which a chilled non-cryogenic coolant such as glycol is circulated, and wherein the material to be cooled is moved along the cooled trough using an auger. The chilling unit is arranged so that it can be mounted on another so that the material is transferred from one to another under the influence of gravity and so that the length of chilling path can be suitably elongated. The troughs are each rotatably supported by a structure which allows rotation to a near inverted position wherein jets of cleaning fluid can be ejected into the interior of the trough.
Abstract translation: 为了冷却食品和类似类型的材料，模块化冷却单元设置有夹套槽，冷却的非低温冷却剂如乙二醇通过其流通，并且其中待冷却的材料沿着冷却的槽移动，使用 螺旋 冷却单元被布置成使得其可以安装在另一个上，使得材料在重力的影响下从一个转移到另一个，并且可以适当地延长冷却路径的长度。 所述槽各自可旋转地支撑在允许旋转到接近倒置位置的结构上，其中清洗流体的喷射可以喷射到槽的内部。
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公开(公告)号：US11525535B1
公开(公告)日：2022-12-13
申请号：US16810397
申请日：2020-03-05
Applicant: Clay Owens , Alan Davison , Chris Clouse
Inventor： Clay Owens , Alan Davison , Chris Clouse
Abstract: A hand disassembly rotational valve coupling for tool less manipulation by a user's hands and fingers using a coupling housing body defining an output seal aperture close to an output handle retention slot and slot lip, where the slot lip has a slot handle gap and an output seal retainer including a coupling handle ring with a first triangulated offset body retention ears and hand graspable handles separated by a ring handle gap for hand assembly and disassembly from the coupling housing body.
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10.发明授权Carboxy, carboalkoxy and carbamile substituted isonitrile radionuclide complexes 失效羧基，烷氧羰基和氨基甲酰取代的异腈核苷配合物
公开(公告)号：US4872561A
公开(公告)日：1989-10-10
申请号：US139289
申请日：1987-12-29
Applicant: Alun G. Jones , Alan Davison , James Kronauge , Michael J. Abrams
Inventor： Alun G. Jones , Alan Davison , James Kronauge , Michael J. Abrams
CPC classification number: C07F13/005 , C07C251/00 , A61K2123/00
Abstract: A coordination complex comprising a radionuclide selected from the class consisting of radioactive isotopes of Tc, Ru, Co, Pt and Re and an isonitrile ligand of the formula:(CNX)R,where X is a lower alkyl group having 1 to 4 carbon atoms, wherein R is selected from the group consisting of COOR.sup.1 and CONR.sup.2 R.sup.3 where R.sup.1 can be H, a pharmaceutically acceptable cation, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms. R.sup.2, and R.sup.3 can be H, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, and R.sup.2 and R.sup.3 can be the same of different is disclosed. Kits that can be used to form these complexes are also disclosed.
Abstract translation: 包含选自Tc，Ru，Co，Pt和Re的放射性同位素的放射性核素的配位络合物和式（CNX）R的异腈配体，其中X是具有1至4个碳原子的低级烷基 其中R选自COOR1和CONR2R3，其中R1可以是H，药学上可接受的阳离子或具有1至4个碳原子的取代或未取代的烷基。 R2和R3可以是H，或者取代或未取代的具有1至4个碳原子的烷基，R2和R3可以是不同的。 还可以公开可用于形成这些络合物的试剂盒。
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