发明授权
- 专利标题: Polyiodinated triglyceride analogs as radiologic agents
- 专利标题(中): 多碘化甘油三酯类似物作为放射剂
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申请号: US774498申请日: 1985-09-10
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公开(公告)号: US4873075A公开(公告)日: 1989-10-10
- 发明人: Raymond E. Counsell , Marc A. Longino , Jamey P. Weichert , Susan P. Schwendner
- 申请人: Raymond E. Counsell , Marc A. Longino , Jamey P. Weichert , Susan P. Schwendner
- 申请人地址: MI Ann Arbor
- 专利权人: The University of Michigan
- 当前专利权人: The University of Michigan
- 当前专利权人地址: MI Ann Arbor
- 主分类号: A61K49/04
- IPC分类号: A61K49/04 ; A61K51/04 ; A61K51/12 ; C07C237/20
摘要:
Novel iodinated arylaliphatic triglyceride analogs, as radiologic agents are liver and hepatocyte site-specific. The triglyceride backbone structure is preferably 1,3-disubstituted or 1,2,3-trisubstituted with, in some embodiments, a 3-substituted-2,4,6-triiodophenyl aliphatic chain wherein the chain has a structure similar to naturally occurring fatty acids. In another embodiment, a monoiodophenyl aliphatic chain is utilized. Any position remaining on the triglyceride backbone is substituted with a saturated or unsaturated aliphatic hydrocarbon chain of the type found in naturally occurring fatty acids. The triglyceride analogs can be radioiodinated. In a preferred embodiment, a lipid emulsion is provided as the carrier vehicle.
公开/授权文献
- US5761182A Optical recording and reproducing apparatus 公开/授权日:1998-06-02
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