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1.发明申请公开(公告)号：US20120128596A1
公开(公告)日：2012-05-24
申请号：US13318546
申请日：2010-05-11
IPC分类号： A61K49/00 , C12Q1/04 , A61P35/00 , C07F9/6596 , C07F9/6558
CPC分类号： A61K49/0032 , A61B5/0071 , A61B5/0084 , A61B5/0088 , A61B5/411 , A61B5/415 , A61B5/418 , A61B5/444 , A61K49/0021 , A61K49/0052
摘要： The invention generally relates to novel fluorescent phospholipid compounds, compositions comprising these compounds, and diagnostic methods utilizing these compounds. A preferred compound of the present invention has the following structural formula: (I)
摘要翻译： 本发明一般涉及新型荧光磷脂化合物，包含这些化合物的组合物和利用这些化合物的诊断方法。 本发明优选的化合物具有以下结构式：（I）
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2.发明申请公开(公告)号：US20100284930A1
公开(公告)日：2010-11-11
申请号：US12463990
申请日：2009-05-11
IPC分类号： A61B5/00
CPC分类号： A61B5/411 , A61B5/0071 , A61B5/0084 , A61B5/0086 , A61B5/415 , A61B5/418 , A61K49/0006 , A61K49/0021 , A61K49/0032
摘要： The invention generally relates to novel fluorescent phospholipid compounds, compositions comprising these compounds, and their use in a variety of diagnostic applications, including fluorescence imaging of tumors. A preferred compound of the present invention has the following structural formula:
摘要翻译： 本发明一般涉及新的荧光磷脂化合物，包含这些化合物的组合物，以及它们在各种诊断应用中的应用，包括肿瘤的荧光成像。 本发明优选的化合物具有以下结构式：
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公开(公告)号：US06645463B1
公开(公告)日：2003-11-11
申请号：US09058715
申请日：1998-04-10
IPC分类号： A61K5100
CPC分类号： A61K49/0461 , A61K9/1075 , A61K9/1275 , A61K49/0433 , A61K49/1806 , A61K51/0406 , A61K51/0478 , A61K51/1217 , B82Y5/00 , Y10S514/938 , Y10S977/829 , Y10S977/905 , Y10S977/927 , Y10S977/93
摘要： A surface-modified lipoprotein-like oil-in-water emulsion useful as a blood-pool selective delivery vehicle for lipophilic imaging agents or lipophilic derivatives of water-soluble imaging agents. The blood-pool selective delivery vehicle remains in the blood for several hours, shows very little early hepatic sequestration, and is cleared from the blood within 24 hours. The mean diameter of the oil phase is less than 150 nm which minimizes sequestration by the reticuloendothelial system. The surface of the oil phase is modified with a polyethyl glycol-modified phospholipid to prevent normal interactions with the receptor sites of the hepatocytes. In radiographic imaging, radioactive or stable, synthetic or semi-synthetic polyhalogenated triglycerides, such as 2-oleoylglycerol-1,3-bis[7-(3-amino-2,4,6-triiodophenyl)heptanoate], or lipid soluble derivatives of traditional water-soluble contrast agents, such as aliphatic esters of iopanoic, diatrizoic, and acetrizoic acid, may be incorporated into the lipophilic core of a lipoprotein-like emulsion particle.
摘要翻译： 用作脂溶性成像剂或水溶性成像剂的亲脂性衍生物的血液池选择性递送载体的表面改性脂蛋白样水包油乳液。 血液池选择性输送载体在血液中保持数小时，显示出非常少的早期肝脏螯合，并在24小时内从血液中清除。 油相的平均直径小于150nm，其最小化网状内皮系统的螯合。 用聚乙二醇修饰的磷脂修饰油相的表面以防止与肝细胞的受体位点的正常相互作用。 放射摄影成像中，放射性或稳定的合成或半合成多卤甘油三酸酯如2-油酰甘油-1,3-双[7-（3-氨基-2,4,6-三碘苯基）庚酸酯]或脂溶性衍生物 的传统的水溶性造影剂，如碘，脂肪族和代谢酸的脂肪族酯可以并入脂蛋白样乳液颗粒的亲脂性核心中。
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公开(公告)号：US10007961B2
公开(公告)日：2018-06-26
申请号：US12556323
申请日：2009-09-09
摘要： A treatment schedule for radiopharmaceuticals is developed by collecting a volumetric history of tissue uptake in identified volumes of interest using emitted-radiation scans and relating this data to a treatment-radiopharmaceutical to develop a quantitatively accurate radiation treatment schedule of delivery amounts and delivery times of the treatment-radiopharmaceutical. This data may also be used to model biological effective dose and to prepare augmenting external radiation beam treatment schedules.
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5.发明申请公开(公告)号：US20120156133A1
公开(公告)日：2012-06-21
申请号：US13403445
申请日：2012-02-23
申请人： Anatoly Pinchuk , Marc Longino , Jamey P. Weichert , William R. Clarke , Abram M. Vaccaro , Irawati Kandela
发明人： Anatoly Pinchuk , Marc Longino , Jamey P. Weichert , William R. Clarke , Abram M. Vaccaro , Irawati Kandela
IPC分类号： A61K51/04 , A61P35/00 , A61K31/685
CPC分类号： A61K51/0408 , A61K31/685 , A61K31/688
摘要： The present invention provides phospholipid ether and alkyl phospholipid compounds and their combinations with other cancer therapy agents. More specifically, the invention relates to the use of phospholipid ether compounds comprising a “cold” isotope of iodine, e.g. 127I, or H, for treating cancer and combinations of phospholipid compounds comprising radioactive (i.e., “hot”) and non-radioactive (i.e., “cold”) isotopes of iodine.
摘要翻译： 本发明提供磷脂醚和烷基磷脂化合物及其与其它癌症治疗剂的组合。 更具体地，本发明涉及包含碘的“冷”同位素的磷脂醚化合物的用途，例如， 127I或H，用于治疗癌症和包含放射性（即“热”）和非放射性（即“冷”）碘同位素的磷脂化合物的组合。
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6.发明申请公开(公告)号：US20110064661A1
公开(公告)日：2011-03-17
申请号：US12879167
申请日：2010-09-10
申请人： Anatoly Pinchuk , Marc Longino , Jamey P. Weichert , William R. Clarke , Abram M. Vaccaro , Irawati Kandela
发明人： Anatoly Pinchuk , Marc Longino , Jamey P. Weichert , William R. Clarke , Abram M. Vaccaro , Irawati Kandela
IPC分类号： A61K51/04 , A61K31/685 , A61K31/688 , A61P35/00
CPC分类号： A61K51/0408 , A61K31/685 , A61K31/688
摘要： The present invention provides phospholipid ether and alkyl phospholipid compounds and their combinations with other cancer therapy agents. More specifically, the invention relates to the use of phospholipid ether compounds comprising a “cold” isotope of iodine, e.g. 127I, or H, for treating cancer and combinations of phospholipid compounds comprising radioactive (i.e., “hot”) and non-radioactive (i.e., “cold”) isotopes of iodine.
摘要翻译： 本发明提供磷脂醚和烷基磷脂化合物及其与其它癌症治疗剂的组合。 更具体地，本发明涉及包含碘的“冷”同位素的磷脂醚化合物的用途，例如， 127I或H，用于治疗癌症和包含放射性（即“热”）和非放射性（即“冷”）碘同位素的磷脂化合物的组合。
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公开(公告)号：US20100284929A1
公开(公告)日：2010-11-11
申请号：US12463978
申请日：2009-05-11
IPC分类号： A61K49/00
CPC分类号： A61K49/0021
摘要： The invention generally relates to the use of novel fluorescent phospholipid ether compounds and compositions comprising these compounds in fluorescence imaging of tumors. A preferred compound of the present invention has the following structural formula:
摘要翻译： 本发明一般涉及新型荧光磷脂醚化合物和包含这些化合物的组合物在肿瘤的荧光成像中的用途。 本发明优选的化合物具有以下结构式：
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公开(公告)号：US07811548B1
公开(公告)日：2010-10-12
申请号：US12463970
申请日：2009-05-11
IPC分类号： A61K51/00
CPC分类号： A61K49/0021 , C07F9/094 , C07F9/5728 , C07F9/59 , C07F9/65583 , C07F9/6561
摘要： The invention generally relates to novel fluorescent phospholipid compounds and compositions comprising these compounds. A preferred compound of the present invention has the following structural formula:
摘要翻译： 本发明一般涉及新型荧光磷脂化合物和包含这些化合物的组合物。 本发明优选的化合物具有以下结构式：
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公开(公告)号：US07582279B2
公开(公告)日：2009-09-01
申请号：US10692311
申请日：2003-10-23
CPC分类号： A61K49/0461 , A61K9/1075 , A61K9/1275 , A61K49/0433 , A61K49/1806 , A61K51/0406 , A61K51/0478 , A61K51/1217 , B82Y5/00 , Y10S514/938 , Y10S977/829 , Y10S977/905 , Y10S977/927 , Y10S977/93
摘要： A surface-modified lipoprotein-like oil-in-water emulsion useful as a blood-pool selective delivery vehicle for lipophilic imaging agents or lipophilic derivatives of water-soluble imaging agents. The blood-pool selective delivery vehicle remains in the blood for several hours, shows very little early hepatic sequestration, and is cleared from the blood within 24 hours. The mean diameter of the oil phase is less than 150 nm which minimizes sequestration by the reticuloendothelial system. The surface of the oil phase is modified with a polyethyl glycol-modified phospholipid to prevent normal interactions with the receptor sites of the hepatocytes. In radiographic imaging, radioactive or stable, synthetic or semi-synthetic polyhalogenated triglycerides, such as 2-oleoylglycerol-1,3-bis[7-(3-amino-2,4,6-triiodophenyl)heptanoate], or lipid soluble derivatives of traditional water-soluble contrast agents, such as aliphatic esters of iopanoic, diatrizoic, and acetrizoic acid, may be incorporated into the lipophilic core of a lipoprotein-like emulsion particle.
摘要翻译： 用作脂溶性成像剂或水溶性成像剂的亲脂性衍生物的血液池选择性递送载体的表面改性脂蛋白样水包油乳液。 血液池选择性输送载体在血液中保持数小时，显示出非常少的早期肝脏螯合，并在24小时内从血液中清除。 油相的平均直径小于150nm，其最小化网状内皮系统的螯合。 用聚乙二醇修饰的磷脂修饰油相的表面以防止与肝细胞的受体位点的正常相互作用。 放射摄影成像中，放射性或稳定的合成或半合成多卤甘油三酸酯如2-油酰甘油-1,3-双[7-（3-氨基-2,4,6-三碘苯基）庚酸酯]或脂溶性衍生物 的传统的水溶性造影剂，如碘，脂肪族和代谢酸的脂肪族酯可以并入脂蛋白样乳液颗粒的亲脂性核心中。
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10.发明申请公开(公告)号：US20090018357A1
公开(公告)日：2009-01-15
申请号：US12156258
申请日：2008-05-30
申请人： Anatoly Pinchuk , Jamey P. Weichert , Marc Longino
发明人： Anatoly Pinchuk , Jamey P. Weichert , Marc Longino
摘要： The present invention discloses boronic acids and esters of phospholipid ether analogs and methods for their synthesis and use. The boronic acids and esters of phospholipid ether analogs described herein can be used in treating cancer and in particular can be used in conjunction with radiation therapy, such as external beam radiation therapy and neutron capture therapy to specifically target and kill cancer cells.
摘要翻译： 本发明公开了硼酸和磷脂醚类似物的酯类及其合成和使用方法。 本文所述的磷酸酯类似物的硼酸和酯可用于治疗癌症，特别是可以与放射治疗结合使用，例如外部束放射治疗和中子俘获治疗以特异性靶向和杀死癌细胞。
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