发明授权
US4891360A 6-amino anthracyclines, process for their preparation and use thereof
失效
6-氨基蒽环霉素，其制备及使用方法
- 专利标题： 6-amino anthracyclines, process for their preparation and use thereof
- 专利标题（中）： 6-氨基蒽环霉素，其制备及使用方法
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申请号： US73109申请日： 1987-07-14
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公开(公告)号： US4891360A公开(公告)日： 1990-01-02
- 发明人: Francesco Angelucci , Mauro Gigli , Sergio Penco
- 申请人： Francesco Angelucci , Mauro Gigli , Sergio Penco
- 申请人地址： ITX Milan
- 专利权人： Farmitalia Carlo Erba S.r.l.
- 当前专利权人： Farmitalia Carlo Erba S.r.l.
- 当前专利权人地址： ITX Milan
- 优先权： GBX8617742 19860721
- 主分类号： A61K31/70
- IPC分类号： A61K31/70 ; A61K31/7028 ; A61K31/7034 ; A61K31/704 ; A61P35/00 ; C07H15/252
摘要：
Anthracycline glycosides having the general formula (A): ##STR1## wherein R.sub.1 is hydrogen, hydroxy or methoxy; R.sub.2 is amino, R.sub.3 is hydrogen or hydroxy and X is hydrogen; and their pharmaceutically acceptable salts; are antitumor agents. The compounds are obtained by reduction of the corresponding 6-nitro derivatives with stannous chloride in presence of sodium acetate or with palladium or charcoal in presence of cyclohexene.
公开/授权文献
- USD394403S Wrist watch 公开/授权日：1998-05-19
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