发明授权
US4892875A Substituted heterocyclylalkyl esters of
1,4-dihydropyridine-3,5-dicarboxylic acids
失效
取代的1,4-二氢吡啶-3,5-二羧酸的杂环基烷基酯
- 专利标题: Substituted heterocyclylalkyl esters of 1,4-dihydropyridine-3,5-dicarboxylic acids
- 专利标题(中): 取代的1,4-二氢吡啶-3,5-二羧酸的杂环基烷基酯
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申请号: US693196申请日: 1985-01-22
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公开(公告)号: US4892875A公开(公告)日: 1990-01-09
- 发明人: Kanji Meguro , Akinobu Nagaoka
- 申请人: Kanji Meguro , Akinobu Nagaoka
- 申请人地址: JPX Osaka
- 专利权人: Takeda Chemical Industries, Ltd.
- 当前专利权人: Takeda Chemical Industries, Ltd.
- 当前专利权人地址: JPX Osaka
- 优先权: WOXPCT/JP/82/00159 19820510; WOXPCT/JP83/00008 19830111
- 主分类号: A61K31/44
- IPC分类号: A61K31/44 ; C07D211/90 ; C07D213/74 ; C07D243/08 ; C07D295/088 ; C07D401/00 ; C07D401/04 ; C07D401/12 ; C07D405/00 ; C07D405/04 ; C07D407/00 ; C07D409/00 ; C07D409/04 ; C07D413/00 ; C07D413/02 ; C07D413/04 ; C07D417/00 ; C07D417/04
摘要:
Dihydropyridine derivatives and acid addition salts thereof which are of use as prophylactic or/and therapeutic drugs for cardiovascular diseases, said dihydropyridine derivatives having the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are the same or different and each is alkyl, cycloalkyl, cycloalkylalkyl or alkoxyalkyl; R.sup.4 and R.sup.5 are the same or different and each is hydrogen, halogen, nitro, trifluoromethyl, alkyl, cycloalkyl, alkoxy, cyano, alkoxycarbonyl or alkylthio; R.sup.6 is hydrogen, alkyl, cycloalkyl, aralkyl, aryl or a pyridyl; X is oxygen, sulfur, vinylene, azomethine or a group of the formula ##STR2## A is alkylene; Ar is aryl or a pyridyl; m is an integer of 1 to 3; n is an integer of 0 to 2.
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