发明授权
US4902699A Oxime of 1, 2, 5, 6-tetrahydropyridine compounds their use as
medicaments and the compositions containing them
失效
1,2,5,6-四氢吡啶的肟化合物用作药物和含有它们的组合物
- 专利标题: Oxime of 1, 2, 5, 6-tetrahydropyridine compounds their use as medicaments and the compositions containing them
- 专利标题(中): 1,2,5,6-四氢吡啶的肟化合物用作药物和含有它们的组合物
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申请号: US234627申请日: 1988-08-22
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公开(公告)号: US4902699A公开(公告)日: 1990-02-20
- 发明人: Emilio Toja , Carla Bonetti , Fernando Barzaghi , Giulio Galliani
- 申请人: Emilio Toja , Carla Bonetti , Fernando Barzaghi , Giulio Galliani
- 申请人地址: FRX Paris
- 专利权人: Roussel Uclaf
- 当前专利权人: Roussel Uclaf
- 当前专利权人地址: FRX Paris
- 优先权: ITX21691 19870821
- 主分类号: A61K31/445
- IPC分类号: A61K31/445 ; A61P25/28 ; C07D211/94
摘要:
Compounds useful in the treatment of patients suffering from senile dementia, Alzheimer's disease or memory defects, of the formula ##STR1## in which R represents hydrogen or a linear, branched or cyclic alkyl, alkenyl, or alkynyl, containing up to 8 carbon atoms, or the radical ##STR2## in which R.sub.1 represents a linear or branched, alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, a linear or branched, saturated or unsaturated, alkoxy containing up to 8 carbon atoms, or aryl containing up to 14 carbon atoms, or the radical ##STR3## in which R.sub.2 represents a linear or branched alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, aryl containing up to 14 carbon atoms, possibly substituted, or aralkyl containing up to 18 carbon atoms, possibly substituted, and R' represents a linear, branched or cyclic alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, as well as their addition salts with organic or mineral acids.
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