发明授权
US4906638A Dextromethorphan potentiator for anticonvulsant composition and method
失效
用于抗惊厥药组合物和方法的右美沙芬增强剂
- 专利标题: Dextromethorphan potentiator for anticonvulsant composition and method
- 专利标题(中): 用于抗惊厥药组合物和方法的右美沙芬增强剂
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申请号: US136751申请日: 1987-12-22
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公开(公告)号: US4906638A公开(公告)日: 1990-03-06
- 发明人: Michael J. Pontecorvo , John W. Ferkany
- 申请人: Michael J. Pontecorvo , John W. Ferkany
- 申请人地址: MD Baltimore
- 专利权人: Nova Pharmaceutical Corporation
- 当前专利权人: Nova Pharmaceutical Corporation
- 当前专利权人地址: MD Baltimore
- 主分类号: A61K31/135
- IPC分类号: A61K31/135 ; A61K31/00 ; A61K31/215 ; A61K31/415 ; A61K31/42 ; A61K31/435 ; A61K31/44 ; A61K31/445 ; A61K31/46 ; A61K31/47 ; A61K31/485 ; A61K31/495 ; A61K31/54 ; A61K31/55 ; A61K31/675 ; A61K45/00 ; A61P25/00 ; A61P25/08 ; A61P43/00
摘要:
A pharmaceutical composition comprises an anti-epileptic drug that does not inhibit, enhance or otherwise modify dextromethorphan binding to the central nervous system dextromethorphan receptor and an effective amount of dextromethorphan to potentiate the anticonvulsant activity of the drug. Other related compounds similar to dextromethorphan which inhibit or enhance dextromethorphan binding to the dextromethorphan site in the brain are also suitable as potentiating agents for the anticonvulsants. A method of treating epilepsy and other convulsions include the steps of introducing to the patient an effective amount of the compound comprising an anti-epileptic drug and potentiating amount of dextromethorphan or one of the related compounds.
公开/授权文献
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