发明授权
- 专利标题: Hydroxamic acids and pharmaceutical compositions containing them, and anti-allergic use thereof
- 专利标题(中): 羟肟酸和含有它们的药物组合物及其抗过敏应用
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申请号: US11096申请日: 1987-02-05
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公开(公告)号: US4906666A公开(公告)日: 1990-03-06
- 发明人: Erhard Reinholz , Walter-Gunar Friebe , Wolfgang Kampe , Jurgen Mertin , Otto-Henning Wilhelms
- 申请人: Erhard Reinholz , Walter-Gunar Friebe , Wolfgang Kampe , Jurgen Mertin , Otto-Henning Wilhelms
- 申请人地址: DEX Mannheim
- 专利权人: Boehringer Mannheim GmbH
- 当前专利权人: Boehringer Mannheim GmbH
- 当前专利权人地址: DEX Mannheim
- 优先权: DEX3604050 19860208
- 主分类号: A61K31/10
- IPC分类号: A61K31/10 ; A61K31/135 ; A61K31/165 ; A61K31/19 ; A61K31/235 ; A61K31/26 ; A61K31/275 ; A61K31/41 ; A61P11/00 ; A61P29/00 ; A61P37/08 ; C07C67/00 ; C07C313/00 ; C07C315/02 ; C07C317/18 ; C07C317/44 ; C07C323/12 ; C07C323/14 ; C07C323/20 ; C07C323/52 ; C07C323/54 ; C07C323/60 ; C07C325/00 ; C07C331/04 ; C07D257/04 ; C07D257/06
摘要:
The present invention provides compounds of the general formula: ##STR1## wherein Ar is a phenyl radical optionally substituted by alkyl, alkenyl, alkoxy, alkylthio, alkanoyl, hydroxyl, hydroxyalkyl, carboxyl, alkoxycarbonyl, carbamoyl, nitro, amino or halogen, A is a straight-chained or branched, saturated or unsaturated C.sub.1 -C.sub.8 aliphatic hydrocarbon radical which is optionally substituted by a hydroxyl group, n is 0, 1 or 2, B is a straight-chained or branched, saturated or unsaturated C.sub.1 -C.sub.8 -aliphatic hydrocarbon radical and R is 5-(1H)-tetrazolyl, --CO--NH-tetrazolyl, ##STR2## CN, SCN, OH, halogen, 5-(1H)-tetrazolylthio, ##STR3## or CO--O--NH--R.sub.1, wherein R.sub.1 is a hydrogen atom, an alkyl radical optionally substituted by cycloalkyl or an alkenyl, cycloalkyl, aralkyl or aryl radical, wherein the aromatic moiety can be substituted by alkyl, alkenyl, alkoxy, alkylthio, alkanoyl, hydroxyl, hydroxyalkyl, carboxyl, alkoxycarbonyl, carbamoyl, nitro, amino or halogen; and the pharmacologically acceptable salts thereof. The present invention also provides processes for preparing these compounds and pharmaceutical compositions containing them for combating allergic diseases.
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