发明授权
- 专利标题： Alpha factor leader sequence directed secretion of insulin
- 专利标题（中）： α因子前导序列导向胰岛素分泌
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申请号： US922288申请日： 1986-10-23
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公开(公告)号： US4914026A公开(公告)日： 1990-04-03
- 发明人: Anthony J. Brake , Lawrence S. Cousens , Mickey S. Urdea , Pablo D. T. Valenzuela
- 申请人： Anthony J. Brake , Lawrence S. Cousens , Mickey S. Urdea , Pablo D. T. Valenzuela
- 申请人地址： CA Emeryville
- 专利权人： Chiron Corporation
- 当前专利权人： Chiron Corporation
- 当前专利权人地址： CA Emeryville
- 主分类号： C07K14/62
- IPC分类号： C07K14/62 ; C12N15/17 ; C12N15/62 ; C12N15/81
摘要：
Methods and compositions are provided for efficient production of polypeptides having insulin activity. The proinsulin gene is joined to secretion and processing signals for expession and secretion in yeast. The product may be obtained in enhanced yield in the nutrient medium.Cell line AB103(PYinsl) was deposited at the A.T.C.C. on Apr. 6, 1983 and given Accession No. 20,670.
公开/授权文献
- USD344493S Computer 公开/授权日：1994-02-22
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